CAJ | 학술논문

观察一氧化氮(NO)水平与肝性脑病的关系。方法：确诊的肝性脑病30例，禁食蛋白质，空腹抽血，经重氮化反应法测量血清中的NO水平，与30例确诊的慢性肝炎血清中的NO水平比较；并比较不同时期患者血清中的NO水平。结果：①肝性脑病患者血清NO值为(105.9±29.5)μmol/L，慢性肝炎患者血清NO值为(67.5±18.9)μmol/L，两者相比有显著性差异(P<0.01)；②肝性脑病昏睡期和昏迷期血清NO值为(122.1±25.3)μmol/L，较前驱期和昏迷前期患者血清NO值(87.4±22.6)μmol/L为高(P<0.01)；③肝性脑病患者血清NO值与血氨值进行相关性分析无明显相关性。结论：肝性脑病患者血清NO值明显增高，并随着肝性脑病的严重程度加重而增加，提示NO水平增高可能是肝性脑病发病的有关因素之一。
관찰일양화담(NO)수평여간성뇌병적관계。방법：학진적간성뇌병30례，금식단백질，공복추혈，경중담화반응법측량혈청중적NO수평，여30례학진적만성간염혈청중적NO수평비교；병비교불동시기환자혈청중적NO수평。결과：①간성뇌병환자혈청NO치위(105.9±29.5)μmol/L，만성간염환자혈청NO치위(67.5±18.9)μmol/L，량자상비유현저성차이(P<0.01)；②간성뇌병혼수기화혼미기혈청NO치위(122.1±25.3)μmol/L，교전구기화혼미전기환자혈청NO치(87.4±22.6)μmol/L위고(P<0.01)；③간성뇌병환자혈청NO치여혈안치진행상관성분석무명현상관성。결론：간성뇌병환자혈청NO치명현증고，병수착간성뇌병적엄중정도가중이증가，제시NO수평증고가능시간성뇌병발병적유관인소지일。
To observe the relationship between nitric oxide and hepatic encephalopathy.Methods: Nitric oxide were detected by enzyme reduction assay from the sera of 30 cases of the patients with he patic encephalopathy and compared with that of chronic virus hepatitis. The level of nitric oxide in different peri ods of hepatic encephalopathy was compared, too. Results:(①The level of nitric oxide in sera of the patients with hepatic encephalopathy was (105.9±29.5)μmol/L, which was significantly different from those in sera of the patients with chronic virus hepatitis (67.5±18.3)μmol/L(P<0.01); ②Among the patients with hepatic encephalopathy the level of nitric oxide in sera of Lethargy and Coma periods was (122.1±25.3)μmol/L, which was higher than that of Prodromal and Precoma periods, (87.4±22.6)μmol/L(P<0.01) ;③In the sera of the patients with hepatic encephalopathy ,the degree of relationship of nitric oxide and ammonia levels were nearly zero correlation. Conclusion:Nitric oxide in sera of the patients with hepatic encephalopathy is higher than that of the patients with chronic virus hepatitis, and increases as serious as hepatic undergoing. The results indicate that the higher nitric oxide level might be one of the causes of hepatic encephalopathy.