解剖学报
解剖學報
해부학보
ACTA ANATOMICA SINICA
2009年
6期
851-856
,共6页
卢伟%杨姝%李琛%师晓燕%陈林%徐瑲%张伟%唐勇
盧偉%楊姝%李琛%師曉燕%陳林%徐瑲%張偉%唐勇
로위%양주%리침%사효연%진림%서장%장위%당용
海马结构%有髓神经纤维%老年改变%体视学%大鼠
海馬結構%有髓神經纖維%老年改變%體視學%大鼠
해마결구%유수신경섬유%노년개변%체시학%대서
Hippocampal formation%Myelinated nerve fibers%Age-related changes%Stereology%Rat
目的 探讨雌性Long-Evans大鼠海马结构及其内有髓神经纤维的老年性改变. 方法 运用透射电子显微镜和体视学方法分别对5只青年(6月龄)、5只中老年(18月龄)和6只老年(28月龄)雌性Long-Evans大鼠海马结构及其内有髓神经纤维进行定量研究. 结果 青年组、中老年组和老年组大鼠的海马结构总体积,海马结构内有髓神经纤维的体积分数和总体积,有髓神经纤维的长度密度和有髓神经纤维平均直径均未见显著性改变.中老年组大鼠海马结构内有髓神经纤维总长度与青年组相比增加了63.6%,老年组有髓神经纤维总长度与中老年组相比下降了47.5%,老年组有髓神经纤维总长度与青年组比较下降了13.8%. 结论 本研究结果进一步支持正常老年大脑的有髓神经纤维存在广泛性老年改变.
目的 探討雌性Long-Evans大鼠海馬結構及其內有髓神經纖維的老年性改變. 方法 運用透射電子顯微鏡和體視學方法分彆對5隻青年(6月齡)、5隻中老年(18月齡)和6隻老年(28月齡)雌性Long-Evans大鼠海馬結構及其內有髓神經纖維進行定量研究. 結果 青年組、中老年組和老年組大鼠的海馬結構總體積,海馬結構內有髓神經纖維的體積分數和總體積,有髓神經纖維的長度密度和有髓神經纖維平均直徑均未見顯著性改變.中老年組大鼠海馬結構內有髓神經纖維總長度與青年組相比增加瞭63.6%,老年組有髓神經纖維總長度與中老年組相比下降瞭47.5%,老年組有髓神經纖維總長度與青年組比較下降瞭13.8%. 結論 本研究結果進一步支持正常老年大腦的有髓神經纖維存在廣汎性老年改變.
목적 탐토자성Long-Evans대서해마결구급기내유수신경섬유적노년성개변. 방법 운용투사전자현미경화체시학방법분별대5지청년(6월령)、5지중노년(18월령)화6지노년(28월령)자성Long-Evans대서해마결구급기내유수신경섬유진행정량연구. 결과 청년조、중노년조화노년조대서적해마결구총체적,해마결구내유수신경섬유적체적분수화총체적,유수신경섬유적장도밀도화유수신경섬유평균직경균미견현저성개변.중노년조대서해마결구내유수신경섬유총장도여청년조상비증가료63.6%,노년조유수신경섬유총장도여중노년조상비하강료47.5%,노년조유수신경섬유총장도여청년조비교하강료13.8%. 결론 본연구결과진일보지지정상노년대뇌적유수신경섬유존재엄범성노년개변.
Objective To explore the changes of the hippocampal formation and the myelinated nerve fibers in the hippocampal formation of aged female Long-Evans rat. Methods The hippocampal formation and the myelinated nerve fibers in the hippocampal formation of 5 young (6-month old), 5 middle-aged (18-month old) and 6 aged (28-month old) female Long-Evans rats were quantitatively investigated with the stereological techniques and transmission electronic microscope technique. Results There were no significant changes in the volume of hippocampal formation, the volume density, the total volume, the length density and the mean diameter of the myelinated nerve fibers in the hippocampal formation among young, middle-aged and aged rats. When compared to that of young rats, the total length of the myelinated nerve fibers in the hippocampal formation of middle-aged rats was significantly increased by 63.6%. When compared to that of middle-aged rats, the total length of the myelinated nerve fibers in the hippocampal formation of aged rats was significantly decreased by 47.5%. When compared to that of young rats, the total length of the myelinated nerve fibers in the hippocampal formation of aged rats was non-significantly decreased by 13.8%. Conclusion Although the reason why the total length of the myelinated nerve fibers in the hippocampal formation of middle-aged rats was longer than that of young rats needs further investigations, the present results together with our previous findings in white matter and cortex further suggest that there are age-related changes of the myelinated nerve fibers in the normal aged brains.
