合成化学
閤成化學
합성화학
CHINESE JOURNAL OF SYNTHETIC CHEMISTRY
2010年
2期
271-272
,共2页
赵乐晶%蔡志强%林晓明%石玉%孙铁民%李祎亮
趙樂晶%蔡誌彊%林曉明%石玉%孫鐵民%李祎亮
조악정%채지강%림효명%석옥%손철민%리의량
查尔酮%氯甲基化反应%药物中间体%合成
查爾酮%氯甲基化反應%藥物中間體%閤成
사이동%록갑기화반응%약물중간체%합성
Chalcone%chloromethylation reaction%drug intermediate%synthesis
以2,4-二羟基苯乙酮为起始原料,经羟基烷基化和氯甲基化反应合成了3个新型查尔酮类衍生物的关键中间体--1-(5-氯甲基-2-羟基-4-烷氧基)苯乙酮,其结构经~1HNMR和ESI-MS确证.
以2,4-二羥基苯乙酮為起始原料,經羥基烷基化和氯甲基化反應閤成瞭3箇新型查爾酮類衍生物的關鍵中間體--1-(5-氯甲基-2-羥基-4-烷氧基)苯乙酮,其結構經~1HNMR和ESI-MS確證.
이2,4-이간기분을동위기시원료,경간기완기화화록갑기화반응합성료3개신형사이동류연생물적관건중간체--1-(5-록갑기-2-간기-4-완양기)분을동,기결구경~1HNMR화ESI-MS학증.
Three novel intermediates of synthesizing Chalcone derivative, 1-(5-chloromethyl-2-hydroxy-4-alkoxy) acetophenones, was synthesized from 2,4-dihydroxyacetophenone by alkylation of hydroxyl and chloromethylation reaction. The structures were confirmed by ~1HNMR and ESI-MS.
