国际皮肤性病学杂志
國際皮膚性病學雜誌
국제피부성병학잡지
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
2012年
4期
238-240
,共3页
自身免疫疾病%B细胞活化因子
自身免疫疾病%B細胞活化因子
자신면역질병%B세포활화인자
Autoimmune diseases%B-cell activating factor
B细胞活化因子影响外周B细胞的存活、成熟和免疫球蛋白的类别转换,对于临床有重要的意义.因自身抗体引起的疾病中均可不同程度的检测到血清B细胞活化因子的浓度增加.同时滑液、肺泡灌洗液、胃肠道灌洗液中都可检测到B细胞活化因子的增多,提示其可能与局部的类别转换与免疫球蛋白的产生有关.在自身免疫性疾病、过敏性疾病、恶性肿瘤及感染的临床诊断与治疗中,B细胞活化因子有重要意义.另外,B细胞活化因子拮抗剂是目前一种新的治疗B细胞相关的自身免疫疾病的手段.
B細胞活化因子影響外週B細胞的存活、成熟和免疫毬蛋白的類彆轉換,對于臨床有重要的意義.因自身抗體引起的疾病中均可不同程度的檢測到血清B細胞活化因子的濃度增加.同時滑液、肺泡灌洗液、胃腸道灌洗液中都可檢測到B細胞活化因子的增多,提示其可能與跼部的類彆轉換與免疫毬蛋白的產生有關.在自身免疫性疾病、過敏性疾病、噁性腫瘤及感染的臨床診斷與治療中,B細胞活化因子有重要意義.另外,B細胞活化因子拮抗劑是目前一種新的治療B細胞相關的自身免疫疾病的手段.
B세포활화인자영향외주B세포적존활、성숙화면역구단백적유별전환,대우림상유중요적의의.인자신항체인기적질병중균가불동정도적검측도혈청B세포활화인자적농도증가.동시활액、폐포관세액、위장도관세액중도가검측도B세포활화인자적증다,제시기가능여국부적유별전환여면역구단백적산생유관.재자신면역성질병、과민성질병、악성종류급감염적림상진단여치료중,B세포활화인자유중요의의.령외,B세포활화인자길항제시목전일충신적치료B세포상관적자신면역질병적수단.
B-cell-activating factor (BAFF) regulates the survival and maturation of peripheral B cells as well as class-switch recombination of immunoglobulins,and also has a range of potential clinical implications.Different degrees of increase have been observed in the serum level of BAFF in patients with autoantibody-induced diseases.Also,the increase of BAFF is noted in synovial,bronchoalveolar and gut lavage fluids in patients with autoimmune diseases,suggesting a potential association of BAFF with local class switching and immunoglobulin production.BAFF plays an important role in the diagnosis and treatment of autoimmune diseases,allergic diseases,malignant tumors and infections.Moreover,BAFF antagonists have been attempted to treat B cell-related autoinmune diseases recently.
