CAJ | 학술논문

目的观察奥美沙坦联合氢氯噻嗪治疗原发性高血压的疗效和不良反应,并与贝那普利联合氨氯地平进行疗效对比.方法将116例原发性中度高血压患者随机分为治疗组和对照组.治疗组予以奥美沙坦、氢氯噻嗪早8:00口服治疗,持续3周；对照组予以贝那普利、氨氯地平,早8:00口服治疗,也持续3周.所有患者治疗前后均测量记录血压,治疗过程中密切观察出现的不良反应,超声观察心脏肥大情况.治疗结束后比较两组疗效和不良反应.结果两组降压疗效和抑制心脏肥大方面差异有统计学意义(均P＜0.05),且前者的不良反应较轻.结论奥美沙坦联合氢氯噻嗪治疗原发性中度高血压优于贝那普利联合氨氯地平的疗效,且能够减轻治疗中出现的不良反应.
목적 관찰오미사탄연합경록새진치료원발성고혈압적료효화불량반응,병여패나보리연합안록지평진행료효대비.방법 장116례원발성중도고혈압환자수궤분위치료조화대조조.치료조여이오미사탄、경록새진조8:00구복치료,지속3주；대조조여이패나보리、안록지평,조8:00구복치료,야지속3주.소유환자치료전후균측량기록혈압,치료과정중밀절관찰출현적불량반응,초성관찰심장비대정황.치료결속후비교량조료효화불량반응.결과 량조강압료효화억제심장비대방면차이유통계학의의(균P＜0.05),차전자적불량반응교경.결론 오미사탄연합경록새진치료원발성중도고혈압우우패나보리연합안록지평적료효,차능구감경치료중출현적불량반응.
ObJective To observe the efficay and adverse reactions of olmesartan combined with hydrochlorothiazide on patients with primary moderate hypertension,compared with the therapy of benazapril associated with amlodipine.Methods 116 primary moderate hypertension patients were randomly divided into the treatment group and control group.Patients in treatment group were treated with olmesartan combined with hydrochlorothiazide oral administration,and control group were given benazapril combined with amlodipine oral administration,which lasted for 3 weeks.Every subject was measured blood pressure before and after the drug administration and observed adverse reaction.Cardiac hypertrophy was detected by UCG.A comparison was made in effectiveness of the drug and cardiac hypertrophy between two groups.Results There was significant difference in effectiveness of two anti-hypertension therapies,and cardiac hypertrophy in the treatment group was lighter than that in control group.Conclusion The therapy of olmesartan combined with hydrochlorothiazide was more effective than that of benazapril combined with amlodipine,also more depressed cardiac hypertrophy.