国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2010年
1期
42-44
,共3页
Toll样受体%类风湿性关节炎%信号传导
Toll樣受體%類風濕性關節炎%信號傳導
Toll양수체%류풍습성관절염%신호전도
Toll-like receptors%Rheumatoid arthritis%Signal transduction
Toll样受体(TLR)是Ⅰ型跨膜受体,在天然免疫和获得性免疫反应中发挥重要作用,近年来被认为是天然免疫系统中的关键受体.TLR通过识别外源性、内源性配体激活天然免疫;同时诱导产生的多种细胞因子是影响初始T细胞分化的关键因素,TLR异常活化可引起Th1、Th2、Th17、Treg细胞功能失衡,从而导致自身免疫性疾病发生.
Toll樣受體(TLR)是Ⅰ型跨膜受體,在天然免疫和穫得性免疫反應中髮揮重要作用,近年來被認為是天然免疫繫統中的關鍵受體.TLR通過識彆外源性、內源性配體激活天然免疫;同時誘導產生的多種細胞因子是影響初始T細胞分化的關鍵因素,TLR異常活化可引起Th1、Th2、Th17、Treg細胞功能失衡,從而導緻自身免疫性疾病髮生.
Toll양수체(TLR)시Ⅰ형과막수체,재천연면역화획득성면역반응중발휘중요작용,근년래피인위시천연면역계통중적관건수체.TLR통과식별외원성、내원성배체격활천연면역;동시유도산생적다충세포인자시영향초시T세포분화적관건인소,TLR이상활화가인기Th1、Th2、Th17、Treg세포공능실형,종이도치자신면역성질병발생.
Toll-like receptors(TLRs), as the family members of type Ⅰ transmembrane receptors, play a pivotal role in both innate and adaptive immune responses. Recently, TLRs are believed to be the cntical receptors in innate immunity . Innate immunity activated by the recognition of exogenous or endogenous by TLRs induces multiple cytokines that is the key factor to affect differentiation of naive T cells. Abnormal activation of TLIRs may cause the functional imbalance of Th1, Th2, Th17 and Treg, resulting in the occurence of autoimmune disease.
