CAJ | 학술논문

目的了解广州市近17年来,结核分枝杆菌临床分离株利福平耐药情况及对其它一线抗结核药物的敏感性分布特征.方法回顾性分析广州市胸科医院1992年2月-2008年7月期间门诊结核病人一线抗结核药物敏感性试验结果.结果 10 167例结核分支杆菌分离株中,耐R菌株1034例,耐H菌株2214例,耐S菌株1073例,耐E菌株622例,总体耐药率为25.80%;在1034例R耐药株中,H、R共同耐药者927例,占R耐药株总数的89.65%,却只占2214例H耐药株的41.87%;而R、S共同耐药者502例,R、E共同耐药者237例,分别占耐R株总数的48.55%及22.92%,明显少于R、H共同耐药者.结论耐RFP菌株绝大部分同时对INH耐药,但反之不然,现有的耐药机制难以解释此种现象,结核杆菌是否存在其它耐药机制有待进一步研究.
목적 료해엄주시근17년래,결핵분지간균림상분리주리복평내약정황급대기타일선항결핵약물적민감성분포특정.방법 회고성분석엄주시흉과의원1992년2월-2008년7월기간문진결핵병인일선항결핵약물민감성시험결과.결과 10 167례결핵분지간균분리주중,내R균주1034례,내H균주2214례,내S균주1073례,내E균주622례,총체내약솔위25.80%;재1034례R내약주중,H、R공동내약자927례,점R내약주총수적89.65%,각지점2214례H내약주적41.87%;이R、S공동내약자502례,R、E공동내약자237례,분별점내R주총수적48.55%급22.92%,명현소우R、H공동내약자.결론 내RFP균주절대부분동시대INH내약,단반지불연,현유적내약궤제난이해석차충현상,결핵간균시부존재기타내약궤제유대진일보연구.
Objective To explore rifampicin-resistant status of mycobacterium tuberculosis isolates in Guangzhou during the recent seventeen years, and their distribution characteristics of susceptibility to other first line anti-tuberculosis drugs. Methods The results of first line anti-tuberculosis drug susceptibility testing performed during the period of February 1992 to July 2008 in clinic patients were retrospectively analyzed. Results Of 10 167 mycobacterium tuberculosis isolates, 1034 were rifampin-resistant, 2214 isoniazid-resistant, 1073 streptomycinresistant, and 622 ethambutol-resistant; with a total drug resistance rate of 25.80%. Of 1034 rifampin-resistant isolates, 927 also developed isoniazid resistance, being 89.65% for the total number of rifampin-resistant isolates but only 41.87% for 2214 isoniazid-resistant isolates. Meanwhile, the number of rifampin- and streptomycin -resistant(502 strains)and rifampin- and ethambutol-resistant(237 strains)isolates was significantly smaller than that of rifampin- and isoniazid-resistant isolats. Conclusions Most of rifampin-resistant isolates also develop resistance to isoniazid, but not vice versa. The existing mechanisms of drug resistance are difficult to completely explain this phenomenon. Wether mycobacterium tuberculosis has other mechanisms of drug resistance requires further research.