中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2010年
9期
1035-1040
,共6页
杨万水%谭玉婷%刘大可%高姗%高静%项永兵
楊萬水%譚玉婷%劉大可%高姍%高靜%項永兵
양만수%담옥정%류대가%고산%고정%항영병
结肠癌%体力活动%前瞻性研究%Meta分析
結腸癌%體力活動%前瞻性研究%Meta分析
결장암%체력활동%전첨성연구%Meta분석
Colon cancer%Physical activity%Prospective study%Meta-analysis
目的 索体力活动与结肠癌发生的病因学联系.方法 集和整理1979-2009年国内外公开发表的体力活动与结肠癌关系的队列研究文献,开展Meta分析.其中,各文献RR值的合并采用倒方差法或DerSimonian-Laird method(D-L)法,剂量-反应关系的评价采用方差加权的最小二乘法.结果 入Meta分析的文献共28篇.与低体力活动者相比,男、女性高体力活动者结肠癌RR值分别为0.75(95%CI:0.66～0.86)、0.85(95%CI:0.76～0.95).高质量文献分析显示体力活动与结肠癌,男性RR=0.74(95%CI:0.61～0.90)、女性接近统计学意义的RR=0.99(95%CI:0.95～1.02).男、女性中均未观察到明显的剂量-反应关系,趋势检验分别为P=0.142和P=0.417.结肠亚部位分析结果显示,增加体力活动与男性近端(右侧)结肠癌与远端(左侧)结肠癌发生均有关联,合并RR值分别为0.62(95%CI:0.45～0.85)和0.74(95%CI:0.56～0.99).结论 增加体力活动可以降低结肠癌发生的危险性.
目的 索體力活動與結腸癌髮生的病因學聯繫.方法 集和整理1979-2009年國內外公開髮錶的體力活動與結腸癌關繫的隊列研究文獻,開展Meta分析.其中,各文獻RR值的閤併採用倒方差法或DerSimonian-Laird method(D-L)法,劑量-反應關繫的評價採用方差加權的最小二乘法.結果 入Meta分析的文獻共28篇.與低體力活動者相比,男、女性高體力活動者結腸癌RR值分彆為0.75(95%CI:0.66～0.86)、0.85(95%CI:0.76～0.95).高質量文獻分析顯示體力活動與結腸癌,男性RR=0.74(95%CI:0.61～0.90)、女性接近統計學意義的RR=0.99(95%CI:0.95～1.02).男、女性中均未觀察到明顯的劑量-反應關繫,趨勢檢驗分彆為P=0.142和P=0.417.結腸亞部位分析結果顯示,增加體力活動與男性近耑(右側)結腸癌與遠耑(左側)結腸癌髮生均有關聯,閤併RR值分彆為0.62(95%CI:0.45～0.85)和0.74(95%CI:0.56～0.99).結論 增加體力活動可以降低結腸癌髮生的危險性.
목적 색체력활동여결장암발생적병인학련계.방법 집화정리1979-2009년국내외공개발표적체력활동여결장암관계적대렬연구문헌,개전Meta분석.기중,각문헌RR치적합병채용도방차법혹DerSimonian-Laird method(D-L)법,제량-반응관계적평개채용방차가권적최소이승법.결과 입Meta분석적문헌공28편.여저체력활동자상비,남、녀성고체력활동자결장암RR치분별위0.75(95%CI:0.66～0.86)、0.85(95%CI:0.76～0.95).고질량문헌분석현시체력활동여결장암,남성RR=0.74(95%CI:0.61～0.90)、녀성접근통계학의의적RR=0.99(95%CI:0.95～1.02).남、녀성중균미관찰도명현적제량-반응관계,추세검험분별위P=0.142화P=0.417.결장아부위분석결과현시,증가체력활동여남성근단(우측)결장암여원단(좌측)결장암발생균유관련,합병RR치분별위0.62(95%CI:0.45～0.85)화0.74(95%CI:0.56～0.99).결론 증가체력활동가이강저결장암발생적위험성.
Objective To explore the relationship between physical activity(PA) and the risk of colon cancer. Methods Cohort studies on physical activity and risk of colon cancer were identified by searching MEDLINE, EMBASE, Chinese Bio-medicine and Chinese Wanfang databases from January 1979 to December 2009. Results from the individual studies were synthetically combined in our study. Inverse variance weighting was used in fixed effects model and the random effects estimate was based on the DerSimonian-Laird method. Variance-weighted least squares method was used for trend test of summarized dose-response data. Results A total of 28 studies were included in our analysis. An inverse association between physical activities and the risk of colon cancer was observed with the relative risks (RR) as 0.75 [95% confidence interval (CI): 0.66-0.86] in males and 0.85(95%CI: 0.76-0.95)in females, respectively. However, the findings from those documents with high quality showed significant and borderline significant associations between PA and colon cancer in both males (RR=0.74, 95% CI: 0.61-0.90) and females (RR=0.99, 95% CI: 0.95-1.02). Meanwhile, the dose-response trend was not observed either in males (P=0.142) or in females (P=0.417). For men, the pooled RRs differed by subsites were 0.62(95%CI:0.45-0.85) and 0.74 (95%CI:0.56-0.99)for highest level PA, compared with lowest level PA in proximal colon and distal colon cancer,respectively. For women, the pooled RRs were 0.84 (95%CI: 0.69-1.01 ) in proximal colon and 0.75(95%CI: 0.53-1.05)in distal colon cancer, respectively. Conclusion These results added to the evidence for the protective effects in colon cancer among men and women.
