国际泌尿系统杂志
國際泌尿繫統雜誌
국제비뇨계통잡지
INTERNATIONAL JOURNAL OF UROLOGY AND NEPHROLOGY
2009年
1期
5-8
,共4页
周振玉%苏昀%胡向农%杨建军%姚茂银
週振玉%囌昀%鬍嚮農%楊建軍%姚茂銀
주진옥%소윤%호향농%양건군%요무은
癌,移行性细胞%膀胱肿瘤%丝氨酸蛋白酶抑制剂
癌,移行性細胞%膀胱腫瘤%絲氨痠蛋白酶抑製劑
암,이행성세포%방광종류%사안산단백매억제제
Carcinoma,Transitional cell%Bladder Neoplasms%Serine proteinase Inhibitors
目的 检测HAI-1基因在膀胱移行细胞癌(BTCC)中的表达,探讨与BTCC临床病理参数间的关系及其临床意义.方法 应用免疫组化SP法检测HAI-1在BTCC及正常膀胱黏膜中的表达,并结合临床病理资料分析.结果 HAl-1在BTCC及正常膀胱组织中均有表达;在BTCC中的表达阳性率明显低于正常膀胱组织,差异有统计学意义(P＜0.001);HAI-1表达随肿瘤病理分级、临床分期的升高、肿瘤转移的发生而显著性降低(P＜0.001).结论 HAI-1异常表达在BTCC的发生发展过程中可能具有重要作用,HAI-1蛋白可作为判断BTCC恶性程度及预后的新型生物学标记.
目的 檢測HAI-1基因在膀胱移行細胞癌(BTCC)中的錶達,探討與BTCC臨床病理參數間的關繫及其臨床意義.方法 應用免疫組化SP法檢測HAI-1在BTCC及正常膀胱黏膜中的錶達,併結閤臨床病理資料分析.結果 HAl-1在BTCC及正常膀胱組織中均有錶達;在BTCC中的錶達暘性率明顯低于正常膀胱組織,差異有統計學意義(P＜0.001);HAI-1錶達隨腫瘤病理分級、臨床分期的升高、腫瘤轉移的髮生而顯著性降低(P＜0.001).結論 HAI-1異常錶達在BTCC的髮生髮展過程中可能具有重要作用,HAI-1蛋白可作為判斷BTCC噁性程度及預後的新型生物學標記.
목적 검측HAI-1기인재방광이행세포암(BTCC)중적표체,탐토여BTCC림상병리삼수간적관계급기림상의의.방법 응용면역조화SP법검측HAI-1재BTCC급정상방광점막중적표체,병결합림상병리자료분석.결과 HAl-1재BTCC급정상방광조직중균유표체;재BTCC중적표체양성솔명현저우정상방광조직,차이유통계학의의(P＜0.001);HAI-1표체수종류병리분급、림상분기적승고、종류전이적발생이현저성강저(P＜0.001).결론 HAI-1이상표체재BTCC적발생발전과정중가능구유중요작용,HAI-1단백가작위판단BTCC악성정도급예후적신형생물학표기.
Objectives To investigate the expression and clinic significance of HAI-1 in bladder transitional cell carcinoma(BTCC).Methodsexpression of HAI-1 in specimens of bladder tmnsitional cell carcinoma and normal bladder tissues were detected by SP of immunohistochemistry;The results were analyzed in relation to the clinicopathological data.Results The expressions of HAI-1 were observed in both normal and tumot tissues of bladder;The protein levels of HAI-1 were significantly higher in normal bladder tissues as compared with BTCC tissues(p＜0.001);A progressive decrease in the protein levels of HAI-1 was observed with increasing tumor grade and clinical stage.Conclusions The abnormal expressions of HAI-1 may be contributed to the development of BTCC;HAI-1 protein may be used as parametem for assessing the malignancy and prognosis of BTCC.
