中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2011年
41期
2939-2941
,共3页
沈鑫华%钱敏才%钮富荣%孙松涛%朱毅平%杨剑虹%林敏%俞柏润%李良%沈仲夏
瀋鑫華%錢敏纔%鈕富榮%孫鬆濤%硃毅平%楊劍虹%林敏%俞柏潤%李良%瀋仲夏
침흠화%전민재%뉴부영%손송도%주의평%양검홍%림민%유백윤%리량%침중하
焦虑症%脑源性神经营养因子%治疗效果
焦慮癥%腦源性神經營養因子%治療效果
초필증%뇌원성신경영양인자%치료효과
Anxiety disorders%Brain-derived neurotrophic factor%Treatment outcome
目的 了解首发广泛性焦虑障碍患者血浆脑源性神经营养因子(BDNF)变化规律.方法 测定34例于2007年1-12月在湖州市第三人民医院就诊的广泛性焦虑障碍首发患者基线、帕罗西汀治疗6周末血浆脑源性神经营养因子水平,同时评定相应时点汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)分值,并与31名正常人(对照组)比较.结果 首发广泛性焦虑障碍患者基线BDNF(80±51) ng/L,较对照组高,与基线HAMA、HAMD评分无显著相关性.治疗6周末(70±49) ng/L与HAMA、HAMD评分均存在显著相关性(分别为r=0.4,P=0;r=0.4,P=0).6周末有效(含痊愈)组和无效组BDNF分别为(60±42)ng/L和(83±55) ng/L,无效组和对照组比较差异有统计学意义；痊愈组和非痊愈组BDNF水平分别为(59±52) ng/L和(73±49) ng/L,非痊愈组和对照组比较差异有统计学意义.结论 首发GAD患者血浆BDNF水平在治疗前较正常人高,治疗达到痊愈的患者可能会降到正常水平.
目的 瞭解首髮廣汎性焦慮障礙患者血漿腦源性神經營養因子(BDNF)變化規律.方法 測定34例于2007年1-12月在湖州市第三人民醫院就診的廣汎性焦慮障礙首髮患者基線、帕囉西汀治療6週末血漿腦源性神經營養因子水平,同時評定相應時點漢密爾頓抑鬱量錶(HAMD)、漢密爾頓焦慮量錶(HAMA)分值,併與31名正常人(對照組)比較.結果 首髮廣汎性焦慮障礙患者基線BDNF(80±51) ng/L,較對照組高,與基線HAMA、HAMD評分無顯著相關性.治療6週末(70±49) ng/L與HAMA、HAMD評分均存在顯著相關性(分彆為r=0.4,P=0;r=0.4,P=0).6週末有效(含痊愈)組和無效組BDNF分彆為(60±42)ng/L和(83±55) ng/L,無效組和對照組比較差異有統計學意義；痊愈組和非痊愈組BDNF水平分彆為(59±52) ng/L和(73±49) ng/L,非痊愈組和對照組比較差異有統計學意義.結論 首髮GAD患者血漿BDNF水平在治療前較正常人高,治療達到痊愈的患者可能會降到正常水平.
목적 료해수발엄범성초필장애환자혈장뇌원성신경영양인자(BDNF)변화규률.방법 측정34례우2007년1-12월재호주시제삼인민의원취진적엄범성초필장애수발환자기선、파라서정치료6주말혈장뇌원성신경영양인자수평,동시평정상응시점한밀이돈억욱량표(HAMD)、한밀이돈초필량표(HAMA)분치,병여31명정상인(대조조)비교.결과 수발엄범성초필장애환자기선BDNF(80±51) ng/L,교대조조고,여기선HAMA、HAMD평분무현저상관성.치료6주말(70±49) ng/L여HAMA、HAMD평분균존재현저상관성(분별위r=0.4,P=0;r=0.4,P=0).6주말유효(함전유)조화무효조BDNF분별위(60±42)ng/L화(83±55) ng/L,무효조화대조조비교차이유통계학의의；전유조화비전유조BDNF수평분별위(59±52) ng/L화(73±49) ng/L,비전유조화대조조비교차이유통계학의의.결론 수발GAD환자혈장BDNF수평재치료전교정상인고,치료체도전유적환자가능회강도정상수평.
Objective To examine the changing pattern of brain-derived neurotrophic factor (BDNF) in the patients with first-episode generalized anxiety disorder (GAD).Methods The levels of plasma BDNF and the Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD) scores were measured in 34 patients with first-episode GAD recruited from our hospital between January and December 2007.At baseline and Week 6,they were treated by paroxetine and compared with 31 healthy participants in the control group.Results The baseline level of BDNF [ (80 ± 51 ) ng/L] in the patients with first-episode GAD was higher than that in the control group and had no significant correlation with HAMA and HAMD scores.But at Week 6,the level of BDNF [(70 ± 49) ng/L] had significant correlations with HAMA and HAMD scores (r=0.4,P=0 and r=0.4,P =0 respectively).At Week 6,the levels of BDNF in the response group (including remission group) and ineffective group were (60 ±42)ng/L and (83 ± 55 ) ng/L respectively.And there was significant difference in the levels of BDNF between the ineffective and control groups.The levels of BDNF in the remission and non-remission groups were (59 ±52) ng/L and (73 ±49) ng/L respectively.And there was significant difference in the levels of BDNF between the non-remission and control groups.Conclusion The pre-treatment levels of plasma BDNF in the patients with first-episode GAD are higher than those of healthy counterparts.But normal levels may be restored if the patients are cured.
