中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2012年
18期
1268-1271
,共4页
高血压%Meta分析%25羟维生素D
高血壓%Meta分析%25羥維生素D
고혈압%Meta분석%25간유생소D
Hypertension%Meta-analysis%25-hydroxyvitamin D
目的 探讨25羟维生素D与高血压之间的关系,为高血压的防治和病因探索提供依据.方法 检索国内外各类大型数据库中近11年发表的有关25羟维生素D与高血压关系的文献,采用荟萃分析的方法,利用Stata11.0软件评价25羟维生素D与高血压之间的关系.结果 荟萃分析表明25羟维生素D缺乏者发生高血压的危险性是25羟维生素D充足者的1.37倍(95％CI1.23～1.53).按照25羟维生素D水平＜35 nmol/L和35～68 nmol/L进行亚组分析得出,在＜35 nmol/L组,25羟维生素D缺乏者发生高血压的危险性为2.02倍(95％CI1.49～2.74),差异有统计学意义(P＜0.05).在35 ～68 nmol/L组,25羟维生素D缺乏者发生高血压的危险性为1.23倍(95％CI1.02 ～1.49),差异有统计学意义(P＜0.05).结论 25羟维生素D与高血压发病之间有联系.
目的 探討25羥維生素D與高血壓之間的關繫,為高血壓的防治和病因探索提供依據.方法 檢索國內外各類大型數據庫中近11年髮錶的有關25羥維生素D與高血壓關繫的文獻,採用薈萃分析的方法,利用Stata11.0軟件評價25羥維生素D與高血壓之間的關繫.結果 薈萃分析錶明25羥維生素D缺乏者髮生高血壓的危險性是25羥維生素D充足者的1.37倍(95％CI1.23～1.53).按照25羥維生素D水平＜35 nmol/L和35～68 nmol/L進行亞組分析得齣,在＜35 nmol/L組,25羥維生素D缺乏者髮生高血壓的危險性為2.02倍(95％CI1.49～2.74),差異有統計學意義(P＜0.05).在35 ～68 nmol/L組,25羥維生素D缺乏者髮生高血壓的危險性為1.23倍(95％CI1.02 ～1.49),差異有統計學意義(P＜0.05).結論 25羥維生素D與高血壓髮病之間有聯繫.
목적 탐토25간유생소D여고혈압지간적관계,위고혈압적방치화병인탐색제공의거.방법 검색국내외각류대형수거고중근11년발표적유관25간유생소D여고혈압관계적문헌,채용회췌분석적방법,이용Stata11.0연건평개25간유생소D여고혈압지간적관계.결과 회췌분석표명25간유생소D결핍자발생고혈압적위험성시25간유생소D충족자적1.37배(95％CI1.23～1.53).안조25간유생소D수평＜35 nmol/L화35～68 nmol/L진행아조분석득출,재＜35 nmol/L조,25간유생소D결핍자발생고혈압적위험성위2.02배(95％CI1.49～2.74),차이유통계학의의(P＜0.05).재35 ～68 nmol/L조,25간유생소D결핍자발생고혈압적위험성위1.23배(95％CI1.02 ～1.49),차이유통계학의의(P＜0.05).결론 25간유생소D여고혈압발병지간유련계.
Objective To explore the association between 25-hydroxyvitamin D level and hypertension so as to provide rationales for developing preventive strategies and understanding the etiology of hypertension.Methods The articles on the association of 25-hydroxyvitamin D level and hypertension were retrieved by searching international and national databases from 2000 to 2011.The relationship between 25-hydroxyvitamin D level and hypertension was assessed by Meta-analysis with Stata11.0 software.Results The results of Meta analysis showed that the pooled OR values of hypertension with 25-hydroxyvitamin D level deficiency and sufficiency was 1.37 ( 95％ CI 1.23 - 1.53 ).Subgroup analysis revealed in 25-hydroxyvitamin D level,can be drawn between 25-hydroxyvitamin D level and the incidence of hypertension was statistically significant.The pooled OR values of hypertension with 25-hydroxyvitamin D level in 35 nmol/L and 35 - 68 nmol/L were 2.02 (95 ％ CI 1.49 - 2.74) and 1.23 (95％ CI 1.02 - 1.49 ) ( P ＜0.05).Conclusions The 25-hydroxyvitamin D level is associated with hypertension.With regards to the question of whether or not the 25-hydroxyvitamin D level deficiency serves as one of the potential risk factor for hypertension,prospective studies of larger sample sizes are warranted.
