CAJ | 학술논문

在观察枳术丸对脾阳虚幼犬模型的治疗作用基础上,比较3种不同剂量枳术丸水煎液的疗效,并研究其对幼犬胃酸分泌量和胃蛋白酶活性的影响.结果显示,枳术丸水煎液中剂量(含生药1.0 g/mL)灌胃疗效最好,使幼犬采食量增加、体重恢复、血虚证指标改善最明显;其次为低剂量(含生药0.5 g/mL)组;高剂量(含生药5.0 g/mL)组和阳性对照组疗效最差;枳术丸水煎液中剂量提高幼犬胃酸分泌量和胃蛋白酶活性最明显.枳术丸水煎液对胃酸分泌量和胃蛋白酶活性的影响可能为其健脾作用机制.
재관찰지술환대비양허유견모형적치료작용기출상,비교3충불동제량지술환수전액적료효,병연구기대유견위산분비량화위단백매활성적영향.결과현시,지술환수전액중제량(함생약1.0 g/mL)관위료효최호,사유견채식량증가、체중회복、혈허증지표개선최명현;기차위저제량(함생약0.5 g/mL)조;고제량(함생약5.0 g/mL)조화양성대조조료효최차;지술환수전액중제량제고유견위산분비량화위단백매활성최명현.지술환수전액대위산분비량화위단백매활성적영향가능위기건비작용궤제.
The therapeutic effects of three different concentrations of Zhizhu decoction for insufficiency of spleen yang in pedo-dog model were observed, and their influences on quantity of gastric acid secretion and activity of pepsin were also studies. The results demonstrated that the therapeutic effects of the middle concentration(containing crude drug 1 g/mL) of Zhizhu decoction by intragastric administration was the best, feed intake, weight recovery and amendment for the hemopenia of pedo-dog was the most obvious. Next was the low-concentration group(containing crude drug 0.5 g/mL), high concentration (containing crude drug 5 g/mL) group and positive control had little therapeutic effects. The middle concentration of Zhizhu decoction could remarkably improve quantity of gastric acid secretion and pepsin activity. The effects on quantity of gastric acid secretion and activity of pepsin may be the mechanism for Zhizhu decoction to strengthen spleen.