CAJ | 학술논문

[目的]探讨当前主要的DNA序列映射方法对蛋白质编码区的预测准确率的影响,寻找有效的映射方法。[方法]以AC（Approximate Correlation）为碱基层的预测准确率的测度,采用FIR（Finite Impulse Response）窄通带滤波器预测算法研究各种映射方法对预测准确率的影响。[结果]在ALLSEQ和HMR195 2个DNA序列集上,Voss法和Z-curve方法是较PN（Paired Numeric）法、EIIP（Electron-Io Interaction Potential）法和复数法更为有效的映射方法。[结论]该研究结果为用预测结果的AC值来验证新映射方法的有效性奠定了基础,对利用生物信息学方法正确揭示DNA序列的结构具有重要意义。
[목적]탐토당전주요적DNA서렬영사방법대단백질편마구적예측준학솔적영향,심조유효적영사방법。[방법]이AC（Approximate Correlation）위감기층적예측준학솔적측도,채용FIR（Finite Impulse Response）착통대려파기예측산법연구각충영사방법대예측준학솔적영향。[결과]재ALLSEQ화HMR195 2개DNA서렬집상,Voss법화Z-curve방법시교PN（Paired Numeric）법、EIIP（Electron-Io Interaction Potential）법화복수법경위유효적영사방법。[결론]해연구결과위용예측결과적AC치래험증신영사방법적유효성전정료기출,대이용생물신식학방법정학게시DNA서렬적결구구유중요의의。
[Objective] To discuss the effects of major mapping methods for DNA sequence on the accuracy of protein coding regions prediction,and to find out the effective mapping methods.[Method] By taking Approximate Correlation（AC） as the full measure of the prediction accuracy at nucleotide level,the windowed narrow pass-band filter（WNPBF） based prediction algorithm was applied to study the effects of different mapping methods on prediction accuracy.[Result] In DNA data sets ALLSEQ and HMR195,the Voss and Z-Curve methods are proved to be more effective mapping methods than paired numeric（PN）,Electron-ion Interaction Potential（EIIP） and complex number methods.[Conclusion] This study lays the foundation to verify the effectiveness of new mapping methods by using the predicted AC value,and it is meaningful to reveal DNA structure by using bioinformatics methods.