CAJ | 학술논문

目的研究维持性血液透析患者透析中高血压(IDH)与炎性反应因子的相关性.方法选择维持性血液透析患者40例,分为IDH组和非IDH组,每组20例.在透析前及透析1、2、4h分别采血,测定C反应蛋白(CRP)、白细胞介素(IL)-1 β、IL-6、肿瘤坏死因子(TNF)-α水平,分析各因素与血压的相关性.结果 IDH组随透析的进行,CRP、IL-1β、IL-6、TNF-α呈升高趋势,非IDH组随透析进行升高趋势不明显；相关性分析显示,CRP(r=0.3652)、IL-1β(r=0.3261)、IL-6 (r=0.3156)、TNF-α(r=0.3324)与血压呈正相关(P＜0.01).结论 CRP、IL-1β、TNF-α、IL-6与IDH存在相关性.
목적 연구유지성혈액투석환자투석중고혈압(IDH)여염성반응인자적상관성.방법 선택유지성혈액투석환자40례,분위IDH조화비IDH조,매조20례.재투석전급투석1、2、4h분별채혈,측정C반응단백(CRP)、백세포개소(IL)-1 β、IL-6、종류배사인자(TNF)-α수평,분석각인소여혈압적상관성.결과 IDH조수투석적진행,CRP、IL-1β、IL-6、TNF-α정승고추세,비IDH조수투석진행승고추세불명현；상관성분석현시,CRP(r=0.3652)、IL-1β(r=0.3261)、IL-6 (r=0.3156)、TNF-α(r=0.3324)여혈압정정상관(P＜0.01).결론 CRP、IL-1β、TNF-α、IL-6여IDH존재상관성.
Objective To study the relationship between intradialytic hypertension (IDH) and inflammatory factors in patients with maintenance hemodialysis.Methods Forty maintenance hemodialysis patients were involved,including 20 patients with IDH (IDH group) and 20 patients without IDH(non-IDH group) during hemodialysis.All of them had no sign of acute infections or other progressive disease.The levels of C-reactive protein (CRP),interleukin (IL)-1 β,IL-6,tumor necrosis factor (TNF)-α were measured by enzyme-linked immunosorbent assay (ELISA) before hemodialysis and 1,2,4 h after hemodialysis.The correlation of hypertension to CRP,IL-1 β,IL-6,TNF-α was analyzed.Results The levels of CRP,IL-1β,IL-6,TNF-α were increased in IDH group with the progress of hemodialysis,but were stable innon-IDH group.Logistic regression analysis indicated that there were positive correlations between CRP (r =0.3652),IL-1β (r =0.3261 ),IL-6(r =03156),TNF- α (r =0.3324) and blood pressure during hemodialysis (P ＜ 0.01 ).Conclusion The levels of CRP,IL-1β,TNF-α,IL-6 are positively related to the IDH in maintenance hemodialysis patients.