中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2012年
16期
17-19
,共3页
任杰远%李书敏%俎蕊%张秋芹%张政
任傑遠%李書敏%俎蕊%張鞦芹%張政
임걸원%리서민%조예%장추근%장정
结肠炎,溃疡性%肿瘤坏死因子α%白细胞介素10%奥沙拉秦
結腸炎,潰瘍性%腫瘤壞死因子α%白細胞介素10%奧沙拉秦
결장염,궤양성%종류배사인자α%백세포개소10%오사랍진
Colitis,ulcerative%Tumor necrosis factor-alpha%Interleukin-10%Olsalazine
目的 探讨奥沙拉秦对慢性溃疡性结肠炎患者血清肿瘤坏死因子β (TNF-β)、白细胞介素10(IL-10)的影响.方法 共纳入60例慢性溃疡性结肠炎患者(病例组),其中慢性复发性患者22例,慢性持续性患者38例,均给予奥沙拉秦治疗,同时从门诊随机抽取60例无溃疡性结肠炎病史者作为对照组.应用免疫透射比浊法检测两组血清TNF-α、IL-10的含量并比较.结果 病例组治疗前血清TNF-d含量明显高于对照组[(57.2±10.1) ng/L比(27.2±6.9) ng/L],而IL-10含量明显低于对照组[(9.2±2.1) ng/L比(17.3±2.9) ng/L],差异有统计学意义(P＜0.05)；病例组慢性持续性患者与慢性复发性患者治疗前TNF-α含量[(56.9±9.9)、(57.3±93) ng/L]明显高于对照组,而IL-10含量[(9.1±2.3)、(8.4±2.5) ng/L]明显低于对照组,差异有统计学意义(P＜0.05).病例组治疗后血清TNF-α含量明显低于治疗前[(28.1±8.9) ng/L比(57.2±10.1 )ng/L],而IL-10含量明显高于治疗前[(13.4±10.7)ng/L 比(9.2±2.1)ng/L],差异有统计学意义(P＜0.05)；慢性持续性患者及慢性复发性患者治疗前后血清TNF-α、IL-10含量比较差异有统计学意义(P＜0.05).结论 奥沙拉秦可显著降低慢性溃疡性结肠炎患者血清TNF-α含量,增加血清IL-10含量,有临床应用价值.
目的 探討奧沙拉秦對慢性潰瘍性結腸炎患者血清腫瘤壞死因子β (TNF-β)、白細胞介素10(IL-10)的影響.方法 共納入60例慢性潰瘍性結腸炎患者(病例組),其中慢性複髮性患者22例,慢性持續性患者38例,均給予奧沙拉秦治療,同時從門診隨機抽取60例無潰瘍性結腸炎病史者作為對照組.應用免疫透射比濁法檢測兩組血清TNF-α、IL-10的含量併比較.結果 病例組治療前血清TNF-d含量明顯高于對照組[(57.2±10.1) ng/L比(27.2±6.9) ng/L],而IL-10含量明顯低于對照組[(9.2±2.1) ng/L比(17.3±2.9) ng/L],差異有統計學意義(P＜0.05)；病例組慢性持續性患者與慢性複髮性患者治療前TNF-α含量[(56.9±9.9)、(57.3±93) ng/L]明顯高于對照組,而IL-10含量[(9.1±2.3)、(8.4±2.5) ng/L]明顯低于對照組,差異有統計學意義(P＜0.05).病例組治療後血清TNF-α含量明顯低于治療前[(28.1±8.9) ng/L比(57.2±10.1 )ng/L],而IL-10含量明顯高于治療前[(13.4±10.7)ng/L 比(9.2±2.1)ng/L],差異有統計學意義(P＜0.05)；慢性持續性患者及慢性複髮性患者治療前後血清TNF-α、IL-10含量比較差異有統計學意義(P＜0.05).結論 奧沙拉秦可顯著降低慢性潰瘍性結腸炎患者血清TNF-α含量,增加血清IL-10含量,有臨床應用價值.
목적 탐토오사랍진대만성궤양성결장염환자혈청종류배사인자β (TNF-β)、백세포개소10(IL-10)적영향.방법 공납입60례만성궤양성결장염환자(병례조),기중만성복발성환자22례,만성지속성환자38례,균급여오사랍진치료,동시종문진수궤추취60례무궤양성결장염병사자작위대조조.응용면역투사비탁법검측량조혈청TNF-α、IL-10적함량병비교.결과 병례조치료전혈청TNF-d함량명현고우대조조[(57.2±10.1) ng/L비(27.2±6.9) ng/L],이IL-10함량명현저우대조조[(9.2±2.1) ng/L비(17.3±2.9) ng/L],차이유통계학의의(P＜0.05)；병례조만성지속성환자여만성복발성환자치료전TNF-α함량[(56.9±9.9)、(57.3±93) ng/L]명현고우대조조,이IL-10함량[(9.1±2.3)、(8.4±2.5) ng/L]명현저우대조조,차이유통계학의의(P＜0.05).병례조치료후혈청TNF-α함량명현저우치료전[(28.1±8.9) ng/L비(57.2±10.1 )ng/L],이IL-10함량명현고우치료전[(13.4±10.7)ng/L 비(9.2±2.1)ng/L],차이유통계학의의(P＜0.05)；만성지속성환자급만성복발성환자치료전후혈청TNF-α、IL-10함량비교차이유통계학의의(P＜0.05).결론 오사랍진가현저강저만성궤양성결장염환자혈청TNF-α함량,증가혈청IL-10함량,유림상응용개치.
Objective To investigate the influence of olsalazine on tumor necrosis factor-alpha (TNF-α) and interleukin-10 (IL-10) in patients with chronic ulcerative colitis.Methods Sixty patients with chronic ulcerative colitis (observation group),including 22 chronic recurrent cases and 38 chronic persistent cases,were enrolled and treated with olsalazine.Meanwhile,60 healthy volunteers without disease history of ulcerative colitis were selected as control group.The concentrations of TNF- α and IL-10 in serum of the two groups were detected by ELISA and compared.Results Before treatment,the concentration of TNF- α in serum of the observation group was significantly higher than that of control group [ (57.2 ± 10.1 )ng/L vs.(27.2 ± 6.9) ng/L],while IL-10 was significantly lower than that of control group[ (9.2 ± 2.1 ) ng/L vs.(17.3 ±2.9) ng/L] (P ＜0.05).Before treatment,the concentration of TNF-α in serum in chronic persistent patients and chronic recurrent patients[ (56.9 ± 9.9),(57.3 ± 9.7) ng/L ] were significantly higher than that in control group,and serum IL-10 in chronic persistent patients and chronic recurrent patients [ (9.1 ± 2.3 ),(8.4 ± 2.5 ) ng/L ] was significantly lower than that in control group (P＜ 0.05 ).The concentration of TNF- α in serum in observation group after treatment was obviously lower than that before treatment [(28.1 ±8.9) ng/L vs.(57.2 ± 10.1 ) ng/L],and IL-10 was obviously higher than that before treatment [(13.4 ± 10.7) ng/L vs.(9.2 ±2.1 )ng/L] (P ＜ 0.05).The concentration of serum TNF-αand IL-10 in chronic persistent and chronic recurrent patients before and after treatment had statistical significance (P＜0.05 ).Conclusions Olsalazine can significantly decrease the concentration of TNF- α and increase the concentration of IL-10 in serum in patients with chronic ulcerative colitis.It is worthy of application in clinic.
