CAJ | 학술논문

Gadd45基因是生长抑制及DNA损伤诱导基因家族中的一员,是电离辐射效应基因之一,在细胞周期调控、DNA损伤修复及细胞凋亡过程中发挥重要作用,这使它成为维持基因组稳定性的重要基因,在肿瘤细胞存活、凋亡信号通路中发挥错综复杂的作用,从而参与肿瘤的发生和发展.
Gadd45기인시생장억제급DNA손상유도기인가족중적일원,시전리복사효응기인지일,재세포주기조공、DNA손상수복급세포조망과정중발휘중요작용,저사타성위유지기인조은정성적중요기인,재종류세포존활、조망신호통로중발휘착종복잡적작용,종이삼여종류적발생화발전.
Gadd45 gene is one of growth arrest and DNA damage-inducible(Gadd)family.It's also a gene induced by ionization radiation.It plays an important role in controlling cell cycle,repairing damaged DNA and in cell apoptosis.This makes it work as an improtant gene in mainteining genomic stability.but more importantly it induces cell apoptosis and is a bridge in the cascade process of apoptosis of tumor cell.At the same time,it takes part in tumorigenesis.