中华病理学杂志
中華病理學雜誌
중화병이학잡지
Chinese Journal of Pathology
2011年
8期
511-516
,共6页
沈旭霞%喻林%毕蕊%杨文涛
瀋旭霞%喻林%畢蕊%楊文濤
침욱하%유림%필예%양문도
卵巢肿瘤%肿瘤分期%免疫组织化学%预后
卵巢腫瘤%腫瘤分期%免疫組織化學%預後
란소종류%종류분기%면역조직화학%예후
Ovarian neoplasms%Neoplasm staging%Immunohistochemistry%Prognosis
目的 初步评估卵巢浆液性癌的两级分级系统在病理诊断和预后判断中的应用价值,探讨低、高级别浆液性癌Pax2、p53和Ki-67的表达及其与预后的相关性.方法 依照两级分级系统对卵巢浆液性癌进行分级,分别选取低级别癌38例,高级别癌100例,观察其临床病理特点,并采用免疫组织化学EnVision法检测癌组织中Pax2、p53和Ki-67的表达情况.结果 (1)低级别组的总生存时间、无病生存时间和5年生存率均显著优于高级别组(P＜0.05).(2)低级别组Pax2的阳性率显著高于高级别组(65.8%比13.0%,P＜0.05),而p53强阳性率显著低于高级别组(13.2%比55.0%,P＜0.05),Ki-67阳性指数显著低于高级别组(13.7%比42.1%,P＜0.05).(3)Pax2阳性组的总生存时间和5年生存率均显著优于阴性组(P＜0.05),而无病生存时间的差异无统计学意义(P＞0.05).p53和Ki-67阳性指数与生存时间的差异无统计学意义(P＞0.05).结论 两级分级系统对卵巢浆液性癌的预后判断有提示意义,在临床病理诊断中具有可行性.Pax2、p53和Ki-67在卵巢低、高级别浆液性癌中的表达差异有统计学意义.与p53和Ki-67相比,Pax2更有可能成为卵巢浆液性癌的一个预后相关指标.
目的 初步評估卵巢漿液性癌的兩級分級繫統在病理診斷和預後判斷中的應用價值,探討低、高級彆漿液性癌Pax2、p53和Ki-67的錶達及其與預後的相關性.方法 依照兩級分級繫統對卵巢漿液性癌進行分級,分彆選取低級彆癌38例,高級彆癌100例,觀察其臨床病理特點,併採用免疫組織化學EnVision法檢測癌組織中Pax2、p53和Ki-67的錶達情況.結果 (1)低級彆組的總生存時間、無病生存時間和5年生存率均顯著優于高級彆組(P＜0.05).(2)低級彆組Pax2的暘性率顯著高于高級彆組(65.8%比13.0%,P＜0.05),而p53彊暘性率顯著低于高級彆組(13.2%比55.0%,P＜0.05),Ki-67暘性指數顯著低于高級彆組(13.7%比42.1%,P＜0.05).(3)Pax2暘性組的總生存時間和5年生存率均顯著優于陰性組(P＜0.05),而無病生存時間的差異無統計學意義(P＞0.05).p53和Ki-67暘性指數與生存時間的差異無統計學意義(P＞0.05).結論 兩級分級繫統對卵巢漿液性癌的預後判斷有提示意義,在臨床病理診斷中具有可行性.Pax2、p53和Ki-67在卵巢低、高級彆漿液性癌中的錶達差異有統計學意義.與p53和Ki-67相比,Pax2更有可能成為卵巢漿液性癌的一箇預後相關指標.
목적 초보평고란소장액성암적량급분급계통재병리진단화예후판단중적응용개치,탐토저、고급별장액성암Pax2、p53화Ki-67적표체급기여예후적상관성.방법 의조량급분급계통대란소장액성암진행분급,분별선취저급별암38례,고급별암100례,관찰기림상병리특점,병채용면역조직화학EnVision법검측암조직중Pax2、p53화Ki-67적표체정황.결과 (1)저급별조적총생존시간、무병생존시간화5년생존솔균현저우우고급별조(P＜0.05).(2)저급별조Pax2적양성솔현저고우고급별조(65.8%비13.0%,P＜0.05),이p53강양성솔현저저우고급별조(13.2%비55.0%,P＜0.05),Ki-67양성지수현저저우고급별조(13.7%비42.1%,P＜0.05).(3)Pax2양성조적총생존시간화5년생존솔균현저우우음성조(P＜0.05),이무병생존시간적차이무통계학의의(P＞0.05).p53화Ki-67양성지수여생존시간적차이무통계학의의(P＞0.05).결론 량급분급계통대란소장액성암적예후판단유제시의의,재림상병리진단중구유가행성.Pax2、p53화Ki-67재란소저、고급별장액성암중적표체차이유통계학의의.여p53화Ki-67상비,Pax2경유가능성위란소장액성암적일개예후상관지표.
Objective To evaluate the two-tier system for the grading of ovarian serous carcinomas,and to analyze Pax2, p53, Ki-67 protein expression and their prognostic values for low- and high-grade ovarian serous carcinomas. Methods A total of 38 cases of low-grade and 100 cases of high-grade ovarian serous carcinomas were selected based on the two-tier grading system. Innnunohistochemistry was used to detect Pax2, p53 and Ki-67 protein expression in all cases. Correlation of the two-tier system with immunohistochemical results and prognostic parameters were performed. Results ( 1 ) The overall survival,disease-free survival and 5-year survival rates were significantly higher in the low-grade serous carcinoma cases than in the high-grade cases ( P ＜ 0. 05 ). (2) Significant differences in protein expressions were found between the low- and high-grade serous carcinomas. The high-grade serous carcinomas had a significantly higher expression level of p53 (55.0% vs 13. 2%, P ＜ 0. 05 ) and Ki-67 (42. 1% vs 13.7%, P ＜ 0. 05 ),while low-grade carcinomas had a significantly higher expression level of Pax2 (65. 8% vs 13.0%,P ＜ 0. 05 ). (3) Pax2 positive cases had a significantly better overall survival and 5-year survival rates than Pax2 negative cases ( P ＜ 0. 05 ). The expressions of p53 and Ki-67 were found to have little correlation with overall survival and disease-free survival( P ＞ 0. 05 ). Conclusions The two-tier system for the grading of ovarian serous carcinomas has a good prognostic value. There are significantly differences in expressions of Pax2, p53 and Ki-67 between low- and high-grade ovarian serous carcinomas. Compared with p53 and Ki-67, Pax2 is likely a better prognostic indicator for ovarian serous carcinoma.
