CAJ | 학술논문

目的初步分析125Ⅰ放射性粒子术中植入内照射治疗晚期胰腺癌的临床疗效.方法对22例手术不能切除的晚期胰腺癌在术中植入125Ⅰ放射性粒子进行组织间内照射.结果全组22例,生存期＞20个月5例,＞10～20个月9例,2～10个月8例,平均生存期(13.47±8.12)个月.CR5例,PR 8例,NC 7例,PD 2例.总有效率(CR+PR)为59％.治疗后9例3级疼痛患者中5例转为1级；13例4级疼痛患者中7例转为2级,2例转为1级.止痛有效率为59％.结论 125Ⅰ放射性粒子术中植入内照射治疗晚期胰腺癌有一定疗效.
목적 초보분석125Ⅰ방사성입자술중식입내조사치료만기이선암적림상료효.방법 대22례수술불능절제적만기이선암재술중식입125Ⅰ방사성입자진행조직간내조사.결과 전조22례,생존기＞20개월5례,＞10～20개월9례,2～10개월8례,평균생존기(13.47±8.12)개월.CR5례,PR 8례,NC 7례,PD 2례.총유효솔(CR+PR)위59％.치료후9례3급동통환자중5례전위1급；13례4급동통환자중7례전위2급,2례전위1급.지통유효솔위59％.결론 125Ⅰ방사성입자술중식입내조사치료만기이선암유일정료효.
Objective To analyze the clinical effects of internal radiation of iodine-125 seed implantation in the treatment of advanced pancreatic carcinoma.Methods 22 patients with unresectable and advanced pancreatic carcinoma were treated by the internal and interstitial radiation using iodine-125 seed implantation.Results Survival of 20 months was observed in 5 patients,10 ～ 20 months in 9 patients,2 ～10 months in 8,patients with an average of (13.47 ± 8.12) months.Among the 22 patients,complete response was obtained in 5 patients,partial response in 8 patients,no response in 7 paticnts,and the other showing PD.The response rate( CR + PR) was 59％.Conclusions Intra - operative internal radiation by iodine - 125 seed implantation does show some therapeutic effects for advanced pancreatic carcinoma.