CAJ | 학술논문

目的了解不同HCV感染途径HBV/HCV重叠感染患者临床特征的差异。方法回顾分析我院1999年5月至2010年5月间HCV和HBV重叠感染具有明确HCV感染途径的患者总133例；利用SPSS16.0软件，统计分析不同HCV感染途径HBV/HCV重叠感染患者的人口学、病毒学和生化学等指标。结果 133例患者中，78例患者因静脉吸毒感染HCV( 1DU)，55例因输血感染HCV（PTCH）。IDU重叠感染患者与PTCH重叠感染患者相比，具有发病年龄较小、HBV和HCV感染病史较短和肝硬化比率低(P＜0.05)；但是IDU重叠感染患者体内ALT（t=4.760，P=0.000）、AST(t =3.798，P=0.000)和TBil(t =4.274，P=0.000)水平比PTCH重叠感染患者明显升高。两组患者的性别构成比率不同(X2= 18.706，P=0.000)。结论输血后感染HCV患者和静脉吸毒感染HCV患者临床特征存在明显差异。输血后感染丙肝患者具有发病较晚、肝硬化较多和肝损伤较轻特点；而静脉吸毒感染丙肝患者具有发病年龄早和肝损伤较重等特点。
목적 료해불동HCV감염도경HBV/HCV중첩감염환자림상특정적차이。방법 회고분석아원1999년5월지2010년5월간HCV화HBV중첩감염구유명학HCV감염도경적환자총133례；이용SPSS16.0연건，통계분석불동HCV감염도경HBV/HCV중첩감염환자적인구학、병독학화생화학등지표。결과 133례환자중，78례환자인정맥흡독감염HCV( 1DU)，55례인수혈감염HCV（PTCH）。IDU중첩감염환자여PTCH중첩감염환자상비，구유발병년령교소、HBV화HCV감염병사교단화간경화비솔저(P＜0.05)；단시IDU중첩감염환자체내ALT（t=4.760，P=0.000）、AST(t =3.798，P=0.000)화TBil(t =4.274，P=0.000)수평비PTCH중첩감염환자명현승고。량조환자적성별구성비솔불동(X2= 18.706，P=0.000)。결론 수혈후감염HCV환자화정맥흡독감염HCV환자림상특정존재명현차이。수혈후감염병간환자구유발병교만、간경화교다화간손상교경특점；이정맥흡독감염병간환자구유발병년령조화간손상교중등특점。
Objective The purpose of this study was to compare the epidemiological, biochemical and virological characteristics among patients co-infected with hepatitis B virus (HBV) and hepatitis C virus (HCV) according to the mode of HCV contamination. MethodsThe study included 133 patients with chronic HBV/HCV co-infection. They were studied and subdivided into two groups ( drug addicts group and Blood transfusion group) according to the mode of HCV contaminnation. The epidemiological, biochemical and virological characteristics were collected. Univariate analysis was performed with the SPSS 16.0. Results 78 patients were infected by the mode of drug addicts(IDU) , whereas 55 were infected by the mode of blood transfusion(PTCH). Patients in drug addicts group had yonger age, shorter HBV and HCV infection history, and lower cirrhosis percentage than those of patients in PTCH group( P ＜ 0. 05 ). However, serum levels of ALT ( t = 4. 760, P = 0. 000 ), AST( t = 3. 798, P--0. 000 ), TBil ( t = 4. 274, P = 0. 000 ) of IDU patients were higher than those of PTCH patients. There was difference of sex composition between two groups (x2 = 18. 706,P =0. 000). Conclusions The clinical characteristics of patients with HBV/HCV coinfection were significantly different among different HCV contamination mode. PTCH patients have the characteristics of older age, more cirrhosis and mild degree of liver injury; IDU patients have the characteristics of yonger age, fewer cirrhosis and severe liver injury.