中华医学遗传学杂志
中華醫學遺傳學雜誌
중화의학유전학잡지
CHINESE JOURNAL OF MEDICAL GENETICS
2010年
6期
668-671
,共4页
王红梅%李南方%姚晓光%洪静%罗文利%常建航
王紅梅%李南方%姚曉光%洪靜%囉文利%常建航
왕홍매%리남방%요효광%홍정%라문리%상건항
神经前体细胞表达发育调控样基因%肥胖%新疆哈萨克族人群
神經前體細胞錶達髮育調控樣基因%肥胖%新疆哈薩剋族人群
신경전체세포표체발육조공양기인%비반%신강합살극족인군
neural precursor cell expressed developmentally downregulated 4-like gene%obesity%Xinjiang Kazakh popilation
目的 研究神经前体细胞表达发育调控样基因rs4149601多态性与新疆哈萨克族人群中心性肥胖的相关性.方法 采取以人群为基础的横断面病例-对照研究方法,采用TaqMan聚合酶链反应对新疆哈萨克族856名自然人群(男性364名、女性492名;其中肥胖478例、对照378名)的rs4149601多态性进行分型,分析其与新疆哈萨克族人群肥胖的相关性.结果 共有853名的基因型分型成功,在总体女性新疆哈萨克族自然人群中,rs414960l多态性的基因型、等位基因在肥胖组及对照组分布差异有统计学意义(P＜0.05).在校正了年龄、吸烟、饮洒和性别等影响因素后,Logistics回归分析显示GG基因型仍与新疆哈萨克族人群中心性肥胖相关(OR=1.479,95%CI:1.103～1.983,P=0.009);协方差分析结果提示携带GG基因型者的腰围高于AA携带者+AG携带者(P=0.028).结论 神经前体细胞表达发育调控样基因的rs4149601多态性与新疆哈萨克族人群中心性肥胖相关,GG基因型可能是哈萨克族人群中心性肥胖的易感因素.
目的 研究神經前體細胞錶達髮育調控樣基因rs4149601多態性與新疆哈薩剋族人群中心性肥胖的相關性.方法 採取以人群為基礎的橫斷麵病例-對照研究方法,採用TaqMan聚閤酶鏈反應對新疆哈薩剋族856名自然人群(男性364名、女性492名;其中肥胖478例、對照378名)的rs4149601多態性進行分型,分析其與新疆哈薩剋族人群肥胖的相關性.結果 共有853名的基因型分型成功,在總體女性新疆哈薩剋族自然人群中,rs414960l多態性的基因型、等位基因在肥胖組及對照組分佈差異有統計學意義(P＜0.05).在校正瞭年齡、吸煙、飲灑和性彆等影響因素後,Logistics迴歸分析顯示GG基因型仍與新疆哈薩剋族人群中心性肥胖相關(OR=1.479,95%CI:1.103～1.983,P=0.009);協方差分析結果提示攜帶GG基因型者的腰圍高于AA攜帶者+AG攜帶者(P=0.028).結論 神經前體細胞錶達髮育調控樣基因的rs4149601多態性與新疆哈薩剋族人群中心性肥胖相關,GG基因型可能是哈薩剋族人群中心性肥胖的易感因素.
목적 연구신경전체세포표체발육조공양기인rs4149601다태성여신강합살극족인군중심성비반적상관성.방법 채취이인군위기출적횡단면병례-대조연구방법,채용TaqMan취합매련반응대신강합살극족856명자연인군(남성364명、녀성492명;기중비반478례、대조378명)적rs4149601다태성진행분형,분석기여신강합살극족인군비반적상관성.결과 공유853명적기인형분형성공,재총체녀성신강합살극족자연인군중,rs414960l다태성적기인형、등위기인재비반조급대조조분포차이유통계학의의(P＜0.05).재교정료년령、흡연、음쇄화성별등영향인소후,Logistics회귀분석현시GG기인형잉여신강합살극족인군중심성비반상관(OR=1.479,95%CI:1.103～1.983,P=0.009);협방차분석결과제시휴대GG기인형자적요위고우AA휴대자+AG휴대자(P=0.028).결론 신경전체세포표체발육조공양기인적rs4149601다태성여신강합살극족인군중심성비반상관,GG기인형가능시합살극족인군중심성비반적역감인소.
Objective To investigate the association of the rs4149601 polymorphisms of neural precursor cell expressed developmentally downregulated 4-like gene (NEDD4L)and obesity in Xinjiang Kazakh population. Methods The rs4149601 polymorphism of the NEDD4L gene was genotyped in a Xinjiang Kazakh general population including 856 subjects (aged 30 to 60 years, 478 obese and 378 control individuals). Results The polymorphism was successfully genotyped in 853 Xinjiang Kazakh subjects. The distribution of the additive model and dominant model (AG+ AA vs. GG) of the rs4149601 polymorphism differed significantly between the case and control in both total and females (all P＜0. 05). After adjusting for confounding factors, logistic regression analysis showed that the rs4149601 polymorphism (in dominant model) was significantly associated with obesity (OR= 1. 479, 95% CI: 1. 103-1. 983, P = 0. 009) in Kazakh. Covariate variance analysis showed that compared with subjects with AA + AG genotypes, the waist circumference was significantly higher in subjects with GG genotype after adjusting for age, smoking and drinking (P=0. 028). Conclusion Tbe genetic variations of the NEDD4L gene may be associated with obesity in Xinjiang Kazakh general population.
