CAJ | 학술논문

以纯度为96%的α-桐酸作为对照,考察了从桐油中经NARP-HPLC分离得到的3组含共轭亚麻酸的甘油三酯对人体肿瘤细胞株ECA-109 (食管癌)、SGC-7901(胃癌)、Bel-7402(肝癌)、LS-174-T(结肠癌)、KB(口腔癌)和正常细胞株 L02(肝细胞)的细胞毒性.结果发现α-桐酸对KB、Bel-7402和SGC-7901细胞的毒性明显弱于3组含共轭亚麻酸的甘油三酯.结果提示,除了α-桐酸的共轭三烯结构是桐油甘油三酯的细胞毒性的物质基础之外,含共轭亚麻酸的甘油三酯的分子结构对其抗肿瘤功效也有重要贡献.
이순도위96%적α-동산작위대조,고찰료종동유중경NARP-HPLC분리득도적3조함공액아마산적감유삼지대인체종류세포주ECA-109 (식관암)、SGC-7901(위암)、Bel-7402(간암)、LS-174-T(결장암)、KB(구강암)화정상세포주 L02(간세포)적세포독성.결과발현α-동산대KB、Bel-7402화SGC-7901세포적독성명현약우3조함공액아마산적감유삼지.결과제시,제료α-동산적공액삼희결구시동유감유삼지적세포독성적물질기출지외,함공액아마산적감유삼지적분자결구대기항종류공효야유중요공헌.
The cytotoxic effects of three groups of triacylglycerols containing conjugated linolenic acid which were isolated from tung oil by NARP-HPLC on five human tumor cell lines including ECA-109 (esophageal carcinoma), SGC-7901 (carcinoma ventriculi), Bel-7402 (hepatoma), LS-174-T (colon carcinoma), KB (mouth epidermal carcinoma), and human normal cell line L02 (liver cell) were investigated,and α-eleostearic acid with a purity of 96% was used as control.The results showed that α-eleostearic acid showed weaker cytotoxicity than three groups of triacylglycerols for KB, Bel-7402, SGC-7901 cell lines. The cytotoxic effect of α-eleostearic acid and triacylglycerols of tung oil against human tumor cells may be attributable to conjugated trienoic structure.The study suggested that molecular structures of triacylglycerols containing conjugated linolenic acids were important for their cytotoxicity to human tumor cells.