CAJ | 학술논문

选择性垂体甲状腺激素抵抗是甲状腺抵抗综合征中的一种少见类型,为一种常染色体显性遗传性疾病.主要由于甲状腺激素受体β亚基基因突变所致.它的临床特征为轻度甲状腺功能亢进,实验室检查提爪游离T3游离T4升高的同时伴有促甲状腺激素的不适当分泌.治疗可选用三碘甲状腺醋酸、右旋T4、溴隐亭等,目前尚无根治方法.
선택성수체갑상선격소저항시갑상선저항종합정중적일충소견류형,위일충상염색체현성유전성질병.주요유우갑상선격소수체β아기기인돌변소치.타적림상특정위경도갑상선공능항진,실험실검사제조유리T3유리T4승고적동시반유촉갑상선격소적불괄당분비.치료가선용삼전갑상선작산、우선T4、추은정등,목전상무근치방법.
Pituitary resistance to thyroid hormone(PRTH) is a kind of autosomal dominant hereditary disease. It is mainly caused by the mutations of the thyroid hormone receptor beta gene. The feature of labora-tory is elevated serum free thyroxine (FT4) and free triiodothyronine (TT3) with inappropriate TSH. 3,5,3'-triiodothyroacetic acid (TRIAC), D-T4, bromocriptine have been used in the therapy of PRTH, however, no radical cure has been found now.