CAJ | 학술논문

重症急性胰腺炎是胰酶异常激活引起的全身炎症反应,受损的胰腺组织可作为抗原或炎性刺激物,使免疫系统和炎症反应中活化的细胞产生炎症介质、细胞因子、促发细胞冈子的级联反应,从而使局部病变发展为全身性的病损过程.促炎因子介导并加重组织损伤,而抗炎因子则平衡前者的损伤作用.抗炎促炎因子的相互作用,导致抗炎反应和促炎反应失衡,全身炎症反应综合征的出现,甚至发展成为多器官功能障碍综合征.
중증급성이선염시이매이상격활인기적전신염증반응,수손적이선조직가작위항원혹염성자격물,사면역계통화염증반응중활화적세포산생염증개질、세포인자、촉발세포강자적급련반응,종이사국부병변발전위전신성적병손과정.촉염인자개도병가중조직손상,이항염인자칙평형전자적손상작용.항염촉염인자적상호작용,도치항염반응화촉염반응실형,전신염증반응종합정적출현,심지발전성위다기관공능장애종합정.
Severe acute pancreatitis is the systemic inflammatory reaction caused by the preternatural activation of trypsogen. The necrotizing pancrea as the antigen or stimulant, activiates immunocyte and in-flammatory cell to release a great deal of cytokines, including proinflammatery factor and anti-inflammatory factor. The former aggravates the damage of constitution, the latter could antigonize the damage of anti-inflam-matory factor. The unbalance of pro-and anti-inflammatory cytokines ,leads to the occurrence of systemic in-flammatory syndrome, even the mutiple organ failure.