中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2009年
6期
975-976
,共2页
沈阳%林揆彬%黄秀纯%陈岳招%陈小丽
瀋暘%林揆彬%黃秀純%陳嶽招%陳小麗
침양%림규빈%황수순%진악초%진소려
危重病%细菌感染%降钙素原%价值
危重病%細菌感染%降鈣素原%價值
위중병%세균감염%강개소원%개치
critical illness%bacterial infections%proealcitonin%values
目的 评价血清降钙素原(PCT)对危重患者感染诊断的临床价值.方法 100例患者分为:细菌感染组56例;非细菌感染组44例,采用微量双夹心免疫发光法测定血清PCT水平.结果 细菌感染组血清PCT浓度(21.54±5.72)μg/L,明显高于非细菌感染组(11.95±4.58)μg/L(t=2.291,P<0.05);细菌感染组APACHE Ⅲ评分(62.44±19.55)分明显高于非细菌感染组(44.56±25.88)分(t=2.195,P<0.05),PCT浓度1.0 μg/L和2.0μg/L比较,前者敏感度(96.5)%高于后者(55.2)%(χ2=3.94,P<0.05),前者特异度(41.7)%低于后者(95.8)%(χ2=4.02,P<0.05);1.5μg/L作为阳性标准时Youden指数和Agreement(83.0%,0.65),明显高于1μg/L和2μg/L(71.7%,0.38;73.6%,0.51)(χ2=3.84,χ2=3.90,χ2=3.99,χ2=3.91,P<0.05);死亡组PCT含量(38.9±12.6)μg/L明显高于存活组(11.8±8.3)μg/L(t=2.398,P<0.05).结论 血清PCT检测对危重患者细菌感染的早期诊断及指导临床治疗具有重要意义.
目的 評價血清降鈣素原(PCT)對危重患者感染診斷的臨床價值.方法 100例患者分為:細菌感染組56例;非細菌感染組44例,採用微量雙夾心免疫髮光法測定血清PCT水平.結果 細菌感染組血清PCT濃度(21.54±5.72)μg/L,明顯高于非細菌感染組(11.95±4.58)μg/L(t=2.291,P<0.05);細菌感染組APACHE Ⅲ評分(62.44±19.55)分明顯高于非細菌感染組(44.56±25.88)分(t=2.195,P<0.05),PCT濃度1.0 μg/L和2.0μg/L比較,前者敏感度(96.5)%高于後者(55.2)%(χ2=3.94,P<0.05),前者特異度(41.7)%低于後者(95.8)%(χ2=4.02,P<0.05);1.5μg/L作為暘性標準時Youden指數和Agreement(83.0%,0.65),明顯高于1μg/L和2μg/L(71.7%,0.38;73.6%,0.51)(χ2=3.84,χ2=3.90,χ2=3.99,χ2=3.91,P<0.05);死亡組PCT含量(38.9±12.6)μg/L明顯高于存活組(11.8±8.3)μg/L(t=2.398,P<0.05).結論 血清PCT檢測對危重患者細菌感染的早期診斷及指導臨床治療具有重要意義.
목적 평개혈청강개소원(PCT)대위중환자감염진단적림상개치.방법 100례환자분위:세균감염조56례;비세균감염조44례,채용미량쌍협심면역발광법측정혈청PCT수평.결과 세균감염조혈청PCT농도(21.54±5.72)μg/L,명현고우비세균감염조(11.95±4.58)μg/L(t=2.291,P<0.05);세균감염조APACHE Ⅲ평분(62.44±19.55)분명현고우비세균감염조(44.56±25.88)분(t=2.195,P<0.05),PCT농도1.0 μg/L화2.0μg/L비교,전자민감도(96.5)%고우후자(55.2)%(χ2=3.94,P<0.05),전자특이도(41.7)%저우후자(95.8)%(χ2=4.02,P<0.05);1.5μg/L작위양성표준시Youden지수화Agreement(83.0%,0.65),명현고우1μg/L화2μg/L(71.7%,0.38;73.6%,0.51)(χ2=3.84,χ2=3.90,χ2=3.99,χ2=3.91,P<0.05);사망조PCT함량(38.9±12.6)μg/L명현고우존활조(11.8±8.3)μg/L(t=2.398,P<0.05).결론 혈청PCT검측대위중환자세균감염적조기진단급지도림상치료구유중요의의.
Objective To evaluate the clinical value of serum procalcitonin (PCT) in the diagnosis of bacte-rial infections in the critically ill patients. Methods A loud d 100 cases of critical patients were divided into bacteri-al infection group(56 cases) and non-bacterial infection group(44 cases). Serum PCT was measured by immunolu-minometric assay. Results The concentration of PCT in bacterial infection group(21.54 ±5.72) μg/L, was signifi-cantly higher than non-bacterial infection group (11. 95±4. 58)μg/L (t =2.291,P<0.05);The APACHE Ⅲ score of bacterial infection group(62. 44 ± 19. 55) cent was significantly higher than non-bacterial infection group(44. 56 ± 25. 88) cent(t = 2. 195 ,P < 0. 05). The concentration of PCT of 1.0μg/L and 2. 0 p.g/L compared to the former sensitivity (96. 5) % higher than the latter (55.2) % (X2 = 3. 94, P < 0. 05), the former specificity (41.7) % lower than the latter (95.8)% (X2 = 4. 02 ,P < 0. 05);1.5μg/L as a positive standard Youden index and the Agreement (83.0 % ,0. 65), were significantly higher than 1 μg/L and 2 μg/L(71.7%, 0. 38 ;73.6% ,0. 51) (X2 = 3.84, X2=3. 90,X2 = 3.992 = 3.91 ,P < 0. 05);The concentration of PCT in death group (38. 9 ±12. 6)μg/L was signifi-canfly higher than the survival group(11.8± 8. 3) μg/L(t =2. 398 ,P <0. 05). Conclusion Serum PCT has clinical values in the diagnosis and therapy of bacterial infections in the critical patients.
