中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2012年
15期
2264-2265
,共2页
西帕依固龈液%牙龈炎%抑菌作用
西帕依固齦液%牙齦炎%抑菌作用
서파의고간액%아간염%억균작용
Xipayiguyinye%Gingivitis%Bacteriostasis
目的 探讨西帕依固龈液在体外抑制牙龈周围可疑致病菌的作用和观察体内防治牙龈炎的疗效.方法 采用琼脂稀释方法测定西帕依固龈液在体外对牙龈卟啉单胞菌、具核梭杆菌和中间普雷沃菌的最低抑菌浓度(MIC)；选择112例单纯性牙龈炎患者,随机平均分为研究组和对照组,研究组(56例)给予西帕依固龈液漱口治疗,对照组(56例)给予不含有效成分的含漱液漱口治疗,两组均治疗7d,观察两组患者治疗前后龈沟出血指数(SBI)与菌斑指数(PLI)变化.结果 两组在治疗前SBI和PLI差异无统计学意义(P＞0.05)；研究组治疗后SBI和PLI均较治疗前显著降低,差异有统计学意义(P＜0.05)；对照组治疗前后SBI和PLI差异均无统计学意义(均P＞0.05)；治疗后研究组SBI和PLI数值显著低于对照组,差异有统计学意义(P＜0.05).结论 西帕依固龈液能明显抑制牙周可疑致病菌,同时可以减少牙菌斑堆积、降低SBI,能很好的改善牙龈健康.
目的 探討西帕依固齦液在體外抑製牙齦週圍可疑緻病菌的作用和觀察體內防治牙齦炎的療效.方法 採用瓊脂稀釋方法測定西帕依固齦液在體外對牙齦卟啉單胞菌、具覈梭桿菌和中間普雷沃菌的最低抑菌濃度(MIC)；選擇112例單純性牙齦炎患者,隨機平均分為研究組和對照組,研究組(56例)給予西帕依固齦液漱口治療,對照組(56例)給予不含有效成分的含漱液漱口治療,兩組均治療7d,觀察兩組患者治療前後齦溝齣血指數(SBI)與菌斑指數(PLI)變化.結果 兩組在治療前SBI和PLI差異無統計學意義(P＞0.05)；研究組治療後SBI和PLI均較治療前顯著降低,差異有統計學意義(P＜0.05)；對照組治療前後SBI和PLI差異均無統計學意義(均P＞0.05)；治療後研究組SBI和PLI數值顯著低于對照組,差異有統計學意義(P＜0.05).結論 西帕依固齦液能明顯抑製牙週可疑緻病菌,同時可以減少牙菌斑堆積、降低SBI,能很好的改善牙齦健康.
목적 탐토서파의고간액재체외억제아간주위가의치병균적작용화관찰체내방치아간염적료효.방법 채용경지희석방법측정서파의고간액재체외대아간계람단포균、구핵사간균화중간보뢰옥균적최저억균농도(MIC)；선택112례단순성아간염환자,수궤평균분위연구조화대조조,연구조(56례)급여서파의고간액수구치료,대조조(56례)급여불함유효성분적함수액수구치료,량조균치료7d,관찰량조환자치료전후간구출혈지수(SBI)여균반지수(PLI)변화.결과 량조재치료전SBI화PLI차이무통계학의의(P＞0.05)；연구조치료후SBI화PLI균교치료전현저강저,차이유통계학의의(P＜0.05)；대조조치료전후SBI화PLI차이균무통계학의의(균P＞0.05)；치료후연구조SBI화PLI수치현저저우대조조,차이유통계학의의(P＜0.05).결론 서파의고간액능명현억제아주가의치병균,동시가이감소아균반퇴적、강저SBI,능흔호적개선아간건강.
Objective To discuss the clinical effect of Xipayinguyinye on oral bacteria in vitro and gingivitis in vivo.Methods Took the method of agar dilution to measure the minimum inhibitory concentration (MIC) of Xipayinguyinye on Porphyromonas gingivalis ( P.gingivalis),Prevotella intermedia ( P.intermedia ) and Fusobacterium nucleatum( F.nucleatum)in vitro;choose 112 patients with simple gingivitis and they were randomly divided into the research group and control group.The research group(56 cases)received the treatment of Xipayiguyinye,while the control group(56 cases)received the treatment without effect components.Both groups received 7 days of treatment and then observed the changes of sulcus bleeding index ( SBI ) and plaque index ( PLI ) before and after the treatment.Results MICof Xipayiguyinye in vitro was 1.0g/L for P.gingivalis and F.nucleatum and 0.5g/L for P.intermedia.There was no statistifically significant difference in SBI and PLI between two groups before the treatment(P ＞0.05) ;there was significant difference in SBI and PLI of research group before and after the treatment ( P ＜ 0.05 ) ; there was no significant difference in SBI and PLI of control group before and after the treatment( P ＞ 0.05 ) ;there was significant difference in SBI and PLI in SBI and PLI between two groups after the treatment ( P ＜ 0.05 ).Conclusion Xipayiguyinye could prevent bacteriostasis well and decrease the accumulation of dental plaque,reduce SBI and improve the health of the gingiva in vivo.
