中华放射学杂志
中華放射學雜誌
중화방사학잡지
Chinese Journal of Radiology
2009年
6期
637-642
,共6页
邓德茂%孟悛非%张朝晖%马立恒%周春香%高振华%张小玲%马玲%林尔坚%潘碧涛%黎燕宁
鄧德茂%孟悛非%張朝暉%馬立恆%週春香%高振華%張小玲%馬玲%林爾堅%潘碧濤%黎燕寧
산덕무%맹전비%장조휘%마립항%주춘향%고진화%장소령%마령%림이견%반벽도%려연저
肌%磁共振成像%腿
肌%磁共振成像%腿
기%자공진성상%퇴
Muscles%Magnetic resonance imaging%Leg
目的 探讨在3 T MR上应用体部相控阵线圈加脊柱表面线圈作为接收线圈进行小腿肌肉DTI的可行性,并优化序列参数,探索理想的层厚和b值.方法 采用完全随机设计方法,先随机选取5名健康志愿者,将脑部DTI序列应用于小腿进行肌肉DTI,根据DTI原始图像及后处理图像存在问题进行初步参数优化并应用于下一步研究;再随机选取5名健康志愿者进行不同层厚的小腿肌肉DTI,对其后处理图像进行质量评分,评分高者为理想层厚并应用于下一步研究;另外随机选取5名健康志愿者进行不同b值的小腿肌肉DTI,对其后处理图像进行质量评分,评分高者为理想b值.图像质量评分采用随机设计的多组秩和检验.结果 将脑部DTI序列应用于小腿进行肌肉DTI,其原始图像及后处理图像存在3个方面问题:原始图像信噪比(SNR)极低,各肌肉显示不清;出现局部肌肉信号丢失,尤以胫骨前肌为著;化学位移和shost伪影比较明显.4.5和6 mm层厚的肌肉显示评分分别(7.0±0.O)、(8.6 4-0.9)和(9.0±0.0)分,信号丢失评分分别(5.0±0.0)、(12.8±2.6)和(13.8±2.2)分,总评分分别(22.0±0.0)、(30.1±3.8)和(31.0±4.1)分,差异均有统计学意义(F值分别为21.000、30.544和12.390;P值均<0.05).4 mm层厚的肌肉显示、信号丢失及总评分均低于5 mm和6 mm层厚(q值分别为4.896、6.120、6.327、7.138、3.863和4.043;P值均<0.05).b值为400 s/mm2<的肌肉显示、信号丢失及总评分分别为(9.0±0.0)、(14.0±2.2)和(33.0±2.2)分,分别高于b值为800 s/mm2[分别为(7.0±0.0)、(6.2±2.2)、(21.8±3.4)分]和1000 s/mm2[分别为(7.0±0.O)、(5.0±0.0)、(20.6±2.2)分]的评分(q值分别为3.873、3.873、6.650、7.672、7.101和5.917;P值均<0.05);b值为600 s/mm2的肌肉显示、信号丢失及总评分分别为(8.2±1.1)、(13.0±2.3)和(30.8±3.8)分,分别高于b值为800和1000 s/nun2的评分(q值分别为3.873、3.873、5.797、6.820、5.326和5.917;P值均<0.05),与b值为400 s/mm2的评分差异无统计学意义(q值分别为2.582、0.852、1.775;P值均>0.05).结论 初步研究结果表明应用3 T MR进行正常人小腿肌肉DTI是可行的.通过优化DTI序列,应用体部相控阵线圈加脊柱表口自I线圈作为接收线圈能获得可以接受的SNR.进行小腿肌肉成像时,以层厚为5 mm、b值为400 s/mm2的图像质量为佳.
目的 探討在3 T MR上應用體部相控陣線圈加脊柱錶麵線圈作為接收線圈進行小腿肌肉DTI的可行性,併優化序列參數,探索理想的層厚和b值.方法 採用完全隨機設計方法,先隨機選取5名健康誌願者,將腦部DTI序列應用于小腿進行肌肉DTI,根據DTI原始圖像及後處理圖像存在問題進行初步參數優化併應用于下一步研究;再隨機選取5名健康誌願者進行不同層厚的小腿肌肉DTI,對其後處理圖像進行質量評分,評分高者為理想層厚併應用于下一步研究;另外隨機選取5名健康誌願者進行不同b值的小腿肌肉DTI,對其後處理圖像進行質量評分,評分高者為理想b值.圖像質量評分採用隨機設計的多組秩和檢驗.結果 將腦部DTI序列應用于小腿進行肌肉DTI,其原始圖像及後處理圖像存在3箇方麵問題:原始圖像信譟比(SNR)極低,各肌肉顯示不清;齣現跼部肌肉信號丟失,尤以脛骨前肌為著;化學位移和shost偽影比較明顯.4.5和6 mm層厚的肌肉顯示評分分彆(7.0±0.O)、(8.6 4-0.9)和(9.0±0.0)分,信號丟失評分分彆(5.0±0.0)、(12.8±2.6)和(13.8±2.2)分,總評分分彆(22.0±0.0)、(30.1±3.8)和(31.0±4.1)分,差異均有統計學意義(F值分彆為21.000、30.544和12.390;P值均<0.05).4 mm層厚的肌肉顯示、信號丟失及總評分均低于5 mm和6 mm層厚(q值分彆為4.896、6.120、6.327、7.138、3.863和4.043;P值均<0.05).b值為400 s/mm2<的肌肉顯示、信號丟失及總評分分彆為(9.0±0.0)、(14.0±2.2)和(33.0±2.2)分,分彆高于b值為800 s/mm2[分彆為(7.0±0.0)、(6.2±2.2)、(21.8±3.4)分]和1000 s/mm2[分彆為(7.0±0.O)、(5.0±0.0)、(20.6±2.2)分]的評分(q值分彆為3.873、3.873、6.650、7.672、7.101和5.917;P值均<0.05);b值為600 s/mm2的肌肉顯示、信號丟失及總評分分彆為(8.2±1.1)、(13.0±2.3)和(30.8±3.8)分,分彆高于b值為800和1000 s/nun2的評分(q值分彆為3.873、3.873、5.797、6.820、5.326和5.917;P值均<0.05),與b值為400 s/mm2的評分差異無統計學意義(q值分彆為2.582、0.852、1.775;P值均>0.05).結論 初步研究結果錶明應用3 T MR進行正常人小腿肌肉DTI是可行的.通過優化DTI序列,應用體部相控陣線圈加脊柱錶口自I線圈作為接收線圈能穫得可以接受的SNR.進行小腿肌肉成像時,以層厚為5 mm、b值為400 s/mm2的圖像質量為佳.
목적 탐토재3 T MR상응용체부상공진선권가척주표면선권작위접수선권진행소퇴기육DTI적가행성,병우화서렬삼수,탐색이상적층후화b치.방법 채용완전수궤설계방법,선수궤선취5명건강지원자,장뇌부DTI서렬응용우소퇴진행기육DTI,근거DTI원시도상급후처리도상존재문제진행초보삼수우화병응용우하일보연구;재수궤선취5명건강지원자진행불동층후적소퇴기육DTI,대기후처리도상진행질량평분,평분고자위이상층후병응용우하일보연구;령외수궤선취5명건강지원자진행불동b치적소퇴기육DTI,대기후처리도상진행질량평분,평분고자위이상b치.도상질량평분채용수궤설계적다조질화검험.결과 장뇌부DTI서렬응용우소퇴진행기육DTI,기원시도상급후처리도상존재3개방면문제:원시도상신조비(SNR)겁저,각기육현시불청;출현국부기육신호주실,우이경골전기위저;화학위이화shost위영비교명현.4.5화6 mm층후적기육현시평분분별(7.0±0.O)、(8.6 4-0.9)화(9.0±0.0)분,신호주실평분분별(5.0±0.0)、(12.8±2.6)화(13.8±2.2)분,총평분분별(22.0±0.0)、(30.1±3.8)화(31.0±4.1)분,차이균유통계학의의(F치분별위21.000、30.544화12.390;P치균<0.05).4 mm층후적기육현시、신호주실급총평분균저우5 mm화6 mm층후(q치분별위4.896、6.120、6.327、7.138、3.863화4.043;P치균<0.05).b치위400 s/mm2<적기육현시、신호주실급총평분분별위(9.0±0.0)、(14.0±2.2)화(33.0±2.2)분,분별고우b치위800 s/mm2[분별위(7.0±0.0)、(6.2±2.2)、(21.8±3.4)분]화1000 s/mm2[분별위(7.0±0.O)、(5.0±0.0)、(20.6±2.2)분]적평분(q치분별위3.873、3.873、6.650、7.672、7.101화5.917;P치균<0.05);b치위600 s/mm2적기육현시、신호주실급총평분분별위(8.2±1.1)、(13.0±2.3)화(30.8±3.8)분,분별고우b치위800화1000 s/nun2적평분(q치분별위3.873、3.873、5.797、6.820、5.326화5.917;P치균<0.05),여b치위400 s/mm2적평분차이무통계학의의(q치분별위2.582、0.852、1.775;P치균>0.05).결론 초보연구결과표명응용3 T MR진행정상인소퇴기육DTI시가행적.통과우화DTI서렬,응용체부상공진선권가척주표구자I선권작위접수선권능획득가이접수적SNR.진행소퇴기육성상시,이층후위5 mm、b치위400 s/mm2적도상질량위가.
Objective To demonstrate the feasibility of DTI in human calf with body phased-array coil and surface coil of spine as receiving coil on 3 T system, and to optimize the parameters of sequence, including slice thickness and b-value. Methods Fifteen healthy volunteers were recruited in this study and randomly divided into three groups. The DTI sequence for head was performed on calf in the first group (5 cases), and the sequence parameters were optimized based on the deficits of the raw and the post-processed DTI images. Then, different slice thickness were applied in the senond group (5 eases) to optimize the slice thickness, and this optimized parameter with the highest score based on quality of the post-processed DTI images was applied in the next step. Finally, different b values were applied in the last group to optimize this parameters. The b value with the highest score based on the quality of the pest-processed was the proper one. Results Three problems existed in the raw and the pest-processed images, when the DTI sequence for brain was used for the calf. First, the SNR of raw images is extremely low. Second, the muscle were unclear on the image with parts of signal lose, especially in the anterior tibialis muscle. Finally, the artifacts due to chemical shift and ghost are quite serious. The scores for muscle display quality with slice thickness of 4 mm , 5 mm and 6 mm were (7.0±0. 0), (8.6±0. 9) and (9.0±0. 0) score respectively, the signal less scores were (5.0±0. 0) and ( 12. 8±2. 6) and ( 13. 8±2. 2) score respectively, and the general score were (22. 0±0. 0) and (30. 1±3.8) and (31.0±4. 1 ) score respectively. The differences of above scores were significant among different slice thickness (F-value were 21. 000 and 30. 544 and 12. 390 respectively, P <0. 05 ). The muscle displaying quality, signal loss and general scores were lowest in group with 4 mm slice thickness (q-value were 4. 896.6. 120,6. 327,7. 138,3. 863 and 4. 043, P < 0. 05 ) o The scores of muscle display quality, signal loss and general for b =400 s/mm2 were (9. 0±0. 0), ( 14. 0± 2. 2 ) and ( 33.0±2. 2 ) score respectively, which were lower than those with b = 800 s/ram2 [(7.0±0.0), (6.2±2.2), (21.8±3.4) score] and b=1000 s/mm2[(7.0±0.0), (5.0±0.0), (20.6±2.2) score] (q-value were 3.873,3.873,6.650,7.672,7. 101 and 5.917, P <0.05)o The scores of muscle displaying quality, signal loss and general for b =600 s/mm2 were (8.2±1.1 ), ( 13.0± 2. 3) and ( 30. 8±3. 8 ) score respectively, which were higher than those with b = 800 s/mm2 and b= 1000 s/nun2 (q-value were 3.873, 3.873, 5.797, 6.820, 5.326 and 5.917, P <0.05).There is no significant difference between b = 600 s/ram2 and 400 s/ram2 ( q-value were 2. 582 and 0. 852 and 1. 775, P > 0. 05 ). Conclusion Our preliminary findings indicate that it is feasible to perform DTI on human calf with 3 T MR. With body phased-array coil and surface coil of spine as receiving coil, the DTI sequence were optimized to acquire enough SNB with slice thickness of 5 mm and b-value of 400 s/mm2.
