白血病·淋巴瘤
白血病·淋巴瘤
백혈병·림파류
JOURNAL OF LEUKEMIA & LYMPHOMA
2012年
3期
149-152
,共4页
林雯%林英城%李蔚冰%王鸿彪%林文照%林穗玲
林雯%林英城%李蔚冰%王鴻彪%林文照%林穗玲
림문%림영성%리위빙%왕홍표%림문조%림수령
淋巴瘤,非霍奇金%肝炎病毒乙型%感染%病例对照研究
淋巴瘤,非霍奇金%肝炎病毒乙型%感染%病例對照研究
림파류,비곽기금%간염병독을형%감염%병례대조연구
Lymphoma,non-Hodgkin%Hepatitis B virus%Infection%Case-control studies
目的 探讨非霍奇金淋巴瘤(NHL)与乙肝病毒(HBV)之间的关系.方法 统计393例NHL患者的乙型肝炎表面抗原(HBsAg)阳性率,并与同期住院的大肠癌患者和门诊健康体检者作比较.结果 NHL患者的HBsAg阳性率高于大肠癌患者和健康体检者,分别为26.5％(104/393)、14.5％(155/1070)和8.8％(47/534) (x2=55.713,P＜0.001)；HBsAg阳性NHL患者中位年龄较HBsAg阴性患者年轻(中位年龄47岁:52岁,t=-1.911,P=0.021)；HBsAg阳性者中以B细胞型居多,为80.8 ％(84/104),T细胞型为15.4％(16/104)( x2=39.152,P＜ 0.001)；而性别、分期、B症状等无差别.B细胞型NHL的HBsAg阳性率明显高于大肠癌患者和健康体检者,分别为29.6％(84/284)、15.5 ％(155/1070)和8.8％(47/534)(Wald统计量分别为25.174和55.139,P＜ 0.001)；而T细胞型NHL的HBsAg阳性率(16.7％)与大肠癌患者和健康体检者的差异无统计学意义.结论 NHL与HBV 感染存在相关性,尤其是B细胞型NHL.
目的 探討非霍奇金淋巴瘤(NHL)與乙肝病毒(HBV)之間的關繫.方法 統計393例NHL患者的乙型肝炎錶麵抗原(HBsAg)暘性率,併與同期住院的大腸癌患者和門診健康體檢者作比較.結果 NHL患者的HBsAg暘性率高于大腸癌患者和健康體檢者,分彆為26.5％(104/393)、14.5％(155/1070)和8.8％(47/534) (x2=55.713,P＜0.001)；HBsAg暘性NHL患者中位年齡較HBsAg陰性患者年輕(中位年齡47歲:52歲,t=-1.911,P=0.021)；HBsAg暘性者中以B細胞型居多,為80.8 ％(84/104),T細胞型為15.4％(16/104)( x2=39.152,P＜ 0.001)；而性彆、分期、B癥狀等無差彆.B細胞型NHL的HBsAg暘性率明顯高于大腸癌患者和健康體檢者,分彆為29.6％(84/284)、15.5 ％(155/1070)和8.8％(47/534)(Wald統計量分彆為25.174和55.139,P＜ 0.001)；而T細胞型NHL的HBsAg暘性率(16.7％)與大腸癌患者和健康體檢者的差異無統計學意義.結論 NHL與HBV 感染存在相關性,尤其是B細胞型NHL.
목적 탐토비곽기금림파류(NHL)여을간병독(HBV)지간적관계.방법 통계393례NHL환자적을형간염표면항원(HBsAg)양성솔,병여동기주원적대장암환자화문진건강체검자작비교.결과 NHL환자적HBsAg양성솔고우대장암환자화건강체검자,분별위26.5％(104/393)、14.5％(155/1070)화8.8％(47/534) (x2=55.713,P＜0.001)；HBsAg양성NHL환자중위년령교HBsAg음성환자년경(중위년령47세:52세,t=-1.911,P=0.021)；HBsAg양성자중이B세포형거다,위80.8 ％(84/104),T세포형위15.4％(16/104)( x2=39.152,P＜ 0.001)；이성별、분기、B증상등무차별.B세포형NHL적HBsAg양성솔명현고우대장암환자화건강체검자,분별위29.6％(84/284)、15.5 ％(155/1070)화8.8％(47/534)(Wald통계량분별위25.174화55.139,P＜ 0.001)；이T세포형NHL적HBsAg양성솔(16.7％)여대장암환자화건강체검자적차이무통계학의의.결론 NHL여HBV 감염존재상관성,우기시B세포형NHL.
Objective To evaluate the association between non-Hodgkin's lymphoma (NHL) and hepatitis B virus (HBV).Methods The positive rate of hepatitis B virus surface antigen (HBsAg) in 393 patients of NHL who were admitted. The colorectal cancer patients and healthy persons were also enrolled as control. Results The positive rate of HBsAg in NHL patients (26.5 ％) was significantly higher than that in colorectal cancer patients (14.5 ％) and healthy persons (8.8 ％),respectively (x2=55.713,P＜0.001).The characteristics of HBV-infected patients with NHL were similar to those who were HBV-uninfected in terms of sex,stage and B symptoms,whereas the HBV-infected patients were younger than the HBV-uninfected patients (the median age was 47ys vs 52ys,t =-1.911,P=0.021).In the HBsAg-positive NHL group,B-cell subtype was much more common than T-cell subtype (80.8 ％ vs 15.4 ％,P=0.043).Regarding colorectal cancer patients and healthy persons as control groups,the positive rate of HBsAg was significantly higher in B-cell NHL patients than that in the control groups, respectively ( 29.6 ％ vs15.5 ％ vs 8.8 ％,Wald value were 25.174 and 55.139,respectively,P＜0.001).The positive rate of HBsAg of HBV between T-cell NHL (16.7 ％) and control groups were not significantly different. Conclusions An association is present between HBV infection and NHL,especially in B-cell subtype.
