CAJ | 학술논문

近年来,国内、国外人类疾病模型动物品种、品系繁多,遗传背景各异.国内基因修饰动物模型发展也很快,这些模型动物既有我们自己研发的,也有从国外引进的.建立动物模型的上游科研工作成绩突出,但宝贵的动物模型建立或引进后,由于种种原因导致动物断种、失去原有生物学特性的案例却屡见不鲜.从人类疾病模型动物的引种、保种、检疫隔离、饲养管理的特殊性等方面加强管理,可有效地控制和避免突变系出现自身修复,转基因动物的基因丢失,敲除基因动物基因复位等问题,从而达到保持其固有生物学特性的目的.
근년래,국내、국외인류질병모형동물품충、품계번다,유전배경각이.국내기인수식동물모형발전야흔쾌,저사모형동물기유아문자기연발적,야유종국외인진적.건립동물모형적상유과연공작성적돌출,단보귀적동물모형건립혹인진후,유우충충원인도치동물단충、실거원유생물학특성적안례각루견불선.종인류질병모형동물적인충、보충、검역격리、사양관리적특수성등방면가강관리,가유효지공제화피면돌변계출현자신수복,전기인동물적기인주실,고제기인동물기인복위등문제,종이체도보지기고유생물학특성적목적.
In recent years,many kinds of animal models of human diseases with different genetic background were developed.Some were established in China,others were imported from abroad.Precious were these animal models,their biological features could be lost for various reasons,for instance,reverse from mutation,lost of modified or constructed gene,etc.This study provided some suggestions for scientific management of the animal models to in terms of quarantine inspection,specific feeding method and methods to maintain gene stability,so as to preserve their biological features.