CAJ | 학술논문

目的评价5-硝基咪唑类药物口服和联合用药治疗细菌性阴道病的疗效和副作用,从而为病人提供经济有效的治疗方法.方法开放的随机前瞻性的研究,将278例有细菌性阴道病的病人分成8组:(1)口服甲硝唑缓释片,每次750 mg,每天1次,连续使用7 d.(2)口服甲硝唑缓释片,每次750 mg,每天1次,连续使用7 d,同时阴道用替硝唑栓,每天250 mg,连续使用7 d.(3)口服替硝唑,每次1 g,首次加倍,每日1次,连服3 d.并使用阴道用替硝唑栓,每天250 mg,连续使用7 d.(4)口服替硝唑,每次1 g,首次加倍,每日1次,连服3 d.(5)口服奥硝唑3 d,每天2次,每次500mg并使用阴道用替硝唑栓,每天250 mg,连续使用7 d.(6)口服奥硝唑3 d,每天2次,每次500 mg.(7)以单一剂量口服塞克硝唑2 g并使用阴道用替硝唑栓,每天250 mg,连续使用7 d.(8)一次性口服塞克硝唑2 g.结果药物联合使用病人的临床治愈率范围为80.00%～86.11%,仅仅口服用药病人的临床治愈率范围56.76%～62.50%.几种5.硝基咪唑类药物口服和阴道联合用药的疗效与仅仅口服用药疗效差异有统计学意义,口服用药组之间和联合用药组之间疗效差异都无统计学意义.结论甲硝唑、替硝唑、奥硝唑、塞克硝唑口服合并替硝唑阴道用药疗效比单独口服好.甲硝唑、替硝唑、奥硝唑、塞克硝唑之间疗效差异无统计学意义,从耐药性及长期用药的安全性和依从性来看,奥硝唑和塞克硝唑具有优势.
목적 평개5-초기미서류약물구복화연합용약치료세균성음도병적료효화부작용,종이위병인제공경제유효적치료방법.방법 개방적수궤전첨성적연구,장278례유세균성음도병적병인분성8조:(1)구복갑초서완석편,매차750 mg,매천1차,련속사용7 d.(2)구복갑초서완석편,매차750 mg,매천1차,련속사용7 d,동시음도용체초서전,매천250 mg,련속사용7 d.(3)구복체초서,매차1 g,수차가배,매일1차,련복3 d.병사용음도용체초서전,매천250 mg,련속사용7 d.(4)구복체초서,매차1 g,수차가배,매일1차,련복3 d.(5)구복오초서3 d,매천2차,매차500mg병사용음도용체초서전,매천250 mg,련속사용7 d.(6)구복오초서3 d,매천2차,매차500 mg.(7)이단일제량구복새극초서2 g병사용음도용체초서전,매천250 mg,련속사용7 d.(8)일차성구복새극초서2 g.결과 약물연합사용병인적림상치유솔범위위80.00%～86.11%,부부구복용약병인적림상치유솔범위56.76%～62.50%.궤충5.초기미서류약물구복화음도연합용약적료효여부부구복용약료효차이유통계학의의,구복용약조지간화연합용약조지간료효차이도무통계학의의.결론 갑초서、체초서、오초서、새극초서구복합병체초서음도용약료효비단독구복호.갑초서、체초서、오초서、새극초서지간료효차이무통계학의의,종내약성급장기용약적안전성화의종성래간,오초서화새극초서구유우세.
Objective To evaluate the efficacy and adverse effects of 5-nitroimidazole derivatives in treatment of bacterial vaginosis (BV). Methods 278 BV patients were randomly divided into 8 groups to be treated with (1) oral metronidazole sustained release tablet 750 mg/day for 7 days, (2) oral metronidazole sustained release tablet 750 mg/day for 7 days and vaginal tinidazlole 250 mg for 7 days, (3) oral tinidazlole 1 g/day for 3 days (2 g for the first dose), (4) oral tinidazlole 1 g/day for 3 days (2 g for the first dose), (5) oral ornidazole 2 x 500 mg/day for 3 days and vaginal tinidazlole 250 mg for 7 days, (6) oral ornidazole 2 × 500 mg/day for 3 days, ( 7 ) oral secnidazole 2 g in a single dose and vaginal tinidazlole 250 mg for 7 days, and (8) oral seenidazole 2 g in a single dose. Results The clinical cure rates of the oral administration groups were 56. 76% - 62. 50%, all significantly lower than those of the oral/vaginal combination groups (80. 00% -86. 11% , all P < 0. 05 ). There was nit significantly difference in efficacy level among the only oral treatment groups and the oral/vaginal combination groups (all P>0.05). Conclusion Combination of oral and vaginal administration of 5-nitroimidazole derivatives is more effective in treatment of BV than oral administration only.