现代检验医学杂志
現代檢驗醫學雜誌
현대검험의학잡지
JOURNAL OF MODERN LABORATORY MEDICINE
2008年
2期
37-39
,共3页
吕树文%张学军%薛承岩%孙立新
呂樹文%張學軍%薛承巖%孫立新
려수문%장학군%설승암%손립신
癌胚抗原信使核糖核酸%癌胚抗原%糖链抗原19-9%糖链抗原12-5%恶性腹腔积液
癌胚抗原信使覈糖覈痠%癌胚抗原%糖鏈抗原19-9%糖鏈抗原12-5%噁性腹腔積液
암배항원신사핵당핵산%암배항원%당련항원19-9%당련항원12-5%악성복강적액
目的 比较癌胚抗原信使核糖核酸(CEA mRNA)、癌胚抗原(CEA)、糖链抗原19-9(CA19-9)、糖链抗原12-5(CA12-5)指标诊断恶性腹腔积液的应用价值.方法 恶性腹腔积液、良性腹腔积液各43份,应用逆转录套式聚合酶链反应(RT-NP-PCR)检测CEA mRNA、磁性抗体分离酶免疫测定技术(MAIA)测定CEA,CA19-9和CA12-5.结果 恶性与良性腹腔积液检测CEA mRNA,CEA,CA19-9,CA12-5的阳性结果[n(%)]为:33(76.7),23(53.5),25(58.1),35(81.4)与3(7.0),4(9.3),0,30(69.8).各指标诊断恶性腹腔积液的特异性、敏感性、阳性预测值、阴性预测值和准确性分别为,CEA mRNA:0.93,0.767,0.917,0.784和0.849,CEA:0.907,0.535,0.852,0.661和0.721,CA19-9:1.0,0.581,1.0,70.5和0.791,CA12-5:0.302,0.814,0.538,0.619和0.558.结论 在诊断恶性腹腔积液方面4个指标中CEA mRNA的价值最高,CA12-5的价值最低,CEA mRNA和CA19-9联检可以进一步提高诊断敏感性.
目的 比較癌胚抗原信使覈糖覈痠(CEA mRNA)、癌胚抗原(CEA)、糖鏈抗原19-9(CA19-9)、糖鏈抗原12-5(CA12-5)指標診斷噁性腹腔積液的應用價值.方法 噁性腹腔積液、良性腹腔積液各43份,應用逆轉錄套式聚閤酶鏈反應(RT-NP-PCR)檢測CEA mRNA、磁性抗體分離酶免疫測定技術(MAIA)測定CEA,CA19-9和CA12-5.結果 噁性與良性腹腔積液檢測CEA mRNA,CEA,CA19-9,CA12-5的暘性結果[n(%)]為:33(76.7),23(53.5),25(58.1),35(81.4)與3(7.0),4(9.3),0,30(69.8).各指標診斷噁性腹腔積液的特異性、敏感性、暘性預測值、陰性預測值和準確性分彆為,CEA mRNA:0.93,0.767,0.917,0.784和0.849,CEA:0.907,0.535,0.852,0.661和0.721,CA19-9:1.0,0.581,1.0,70.5和0.791,CA12-5:0.302,0.814,0.538,0.619和0.558.結論 在診斷噁性腹腔積液方麵4箇指標中CEA mRNA的價值最高,CA12-5的價值最低,CEA mRNA和CA19-9聯檢可以進一步提高診斷敏感性.
목적 비교암배항원신사핵당핵산(CEA mRNA)、암배항원(CEA)、당련항원19-9(CA19-9)、당련항원12-5(CA12-5)지표진단악성복강적액적응용개치.방법 악성복강적액、량성복강적액각43빈,응용역전록투식취합매련반응(RT-NP-PCR)검측CEA mRNA、자성항체분리매면역측정기술(MAIA)측정CEA,CA19-9화CA12-5.결과 악성여량성복강적액검측CEA mRNA,CEA,CA19-9,CA12-5적양성결과[n(%)]위:33(76.7),23(53.5),25(58.1),35(81.4)여3(7.0),4(9.3),0,30(69.8).각지표진단악성복강적액적특이성、민감성、양성예측치、음성예측치화준학성분별위,CEA mRNA:0.93,0.767,0.917,0.784화0.849,CEA:0.907,0.535,0.852,0.661화0.721,CA19-9:1.0,0.581,1.0,70.5화0.791,CA12-5:0.302,0.814,0.538,0.619화0.558.결론 재진단악성복강적액방면4개지표중CEA mRNA적개치최고,CA12-5적개치최저,CEA mRNA화CA19-9련검가이진일보제고진단민감성.
