CAJ | 학술논문

目的探讨弥漫性大B细胞淋巴瘤(DLBCL)的临床病理特征、免疫表型,以提高对DLBCL的诊断水平.方法对22例DLBCL患者进行回顾性分析,复习组织形态和临床表现,补充完善所有患者CD20、CD3、CD10、bcl-6、MUM-1、Ki-67免疫表型测定,为与其他肿瘤相鉴别,对精原细胞瘤、间变性大细胞性淋巴瘤、母细胞型套细胞淋巴瘤部分病例检测AE1/3、PLAP、CD30、ALK、CD5和CyclinD1.结果 22例患者均为原发DLBCL,男性14例,女性8例,年龄21～71岁,平均48岁;13例结内,9例结外.生发中心细胞(CGB)型13例(结内7例,结外6例),非CGB(non-CGB)型9例(结内6例,结外3例),结合临床和组织形态学17例可诊断,再结合免疫组织化学22例均可诊断.结论 DLBCL形态学、免疫表型及临床表现有一定的特征性,三者相结合能较准确诊断.
목적 탐토미만성대B세포림파류(DLBCL)적림상병리특정、면역표형,이제고대DLBCL적진단수평.방법 대22례DLBCL환자진행회고성분석,복습조직형태화림상표현,보충완선소유환자CD20、CD3、CD10、bcl-6、MUM-1、Ki-67면역표형측정,위여기타종류상감별,대정원세포류、간변성대세포성림파류、모세포형투세포림파류부분병례검측AE1/3、PLAP、CD30、ALK、CD5화CyclinD1.결과 22례환자균위원발DLBCL,남성14례,녀성8례,년령21～71세,평균48세;13례결내,9례결외.생발중심세포(CGB)형13례(결내7례,결외6례),비CGB(non-CGB)형9례(결내6례,결외3례),결합림상화조직형태학17례가진단,재결합면역조직화학22례균가진단.결론 DLBCL형태학、면역표형급림상표현유일정적특정성,삼자상결합능교준학진단.
Objective To investigate the clinicopathological characteristics and immunopheotype of diffuse large B-cell lymphoma (DLBCL) in order to improve diagnosis and therapy efficacy. Methods The clinical, immunophenotypical and histopathological features of 22 cases of DLBCL patients were studied retrospectively. The expressions of CD20, CD30, CD10, bcl-6, MUM-1, Ki-67 and CD3o of all patients, and CD5,CyclinD1, Lysozyme,AE1/3 and PLAP of patients with differential cancer, seminoma, anaplastic large cell lymphoma and blastic variant of mantle cell lymphoma were detected by EnVision Immunohistochemical technique. Results All patients were primary systemic DLBCL. All of 22 patients, 14 males and 8 females,average 48(21-71) years old, were primary DLBCL, including 13 cases of germinal centre B-cell-like(GCB) (7 cases of intra-node and 6 extra-node) and 9 cases non-GCB (6 intra-node and 3 extra-node). Conclusion The favorable diagnosis of DLBCL may be achieved by combination of clinical histological and immunological features.