中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2012年
10期
20-22
,共3页
梁伟军%胡成平%宋敏%顾其华%陈红梅
樑偉軍%鬍成平%宋敏%顧其華%陳紅梅
량위군%호성평%송민%고기화%진홍매
肺肿瘤%预后%抗肿瘤联合化疗方案%生存分析
肺腫瘤%預後%抗腫瘤聯閤化療方案%生存分析
폐종류%예후%항종류연합화료방안%생존분석
Lung neoplasms%Prognosis%Antineoplastic combined chemotherapy protocols%Survival analysis
目的 探讨非小细胞肺癌(NSCLC)患者术后生存影响因素.方法 回顾性分析131例NSCLC患者的临床资料和生存情况,根据治疗方法不同分为两组,化疗组86例(均为第三代化疗药物加铂类方案化疗2个周期以上),未化疗组45例(均因患者意愿未行任何方案化疗).用Kaplan-Meier法进行生存分析,用Cox比例风险回归模型进行多因素生存分析.结果 鳞癌76例,支气管肺泡癌8例,腺癌35例,腺鳞癌12例,中位生存期分别为60、54、34、24个月,差异有统计学意义(P＜0.05)；ⅠB期化疗组26例与未化疗组17例中位生存期分别为75、76个月,差异无统计学意义(P＞0.05)；多因素分析表明肿块大小、T分期、N分期和化疗情况为影响生存期的独立因素(P值分别为0.080、0.002、0.000、0.029).结论 鳞癌、支气管肺泡癌手术预后相对较好；ⅠB期手术患者术后含铂类方案化疗不能延长生存期；肿块大小、T分期、N分期、化疗情况是NSCLC手术患者的独立预后因素.
目的 探討非小細胞肺癌(NSCLC)患者術後生存影響因素.方法 迴顧性分析131例NSCLC患者的臨床資料和生存情況,根據治療方法不同分為兩組,化療組86例(均為第三代化療藥物加鉑類方案化療2箇週期以上),未化療組45例(均因患者意願未行任何方案化療).用Kaplan-Meier法進行生存分析,用Cox比例風險迴歸模型進行多因素生存分析.結果 鱗癌76例,支氣管肺泡癌8例,腺癌35例,腺鱗癌12例,中位生存期分彆為60、54、34、24箇月,差異有統計學意義(P＜0.05)；ⅠB期化療組26例與未化療組17例中位生存期分彆為75、76箇月,差異無統計學意義(P＞0.05)；多因素分析錶明腫塊大小、T分期、N分期和化療情況為影響生存期的獨立因素(P值分彆為0.080、0.002、0.000、0.029).結論 鱗癌、支氣管肺泡癌手術預後相對較好；ⅠB期手術患者術後含鉑類方案化療不能延長生存期；腫塊大小、T分期、N分期、化療情況是NSCLC手術患者的獨立預後因素.
목적 탐토비소세포폐암(NSCLC)환자술후생존영향인소.방법 회고성분석131례NSCLC환자적림상자료화생존정황,근거치료방법불동분위량조,화료조86례(균위제삼대화료약물가박류방안화료2개주기이상),미화료조45례(균인환자의원미행임하방안화료).용Kaplan-Meier법진행생존분석,용Cox비례풍험회귀모형진행다인소생존분석.결과 린암76례,지기관폐포암8례,선암35례,선린암12례,중위생존기분별위60、54、34、24개월,차이유통계학의의(P＜0.05)；ⅠB기화료조26례여미화료조17례중위생존기분별위75、76개월,차이무통계학의의(P＞0.05)；다인소분석표명종괴대소、T분기、N분기화화료정황위영향생존기적독립인소(P치분별위0.080、0.002、0.000、0.029).결론 린암、지기관폐포암수술예후상대교호；ⅠB기수술환자술후함박류방안화료불능연장생존기；종괴대소、T분기、N분기、화료정황시NSCLC수술환자적독립예후인소.
Objective To investigate the prognostic factors of non-small cell lung cancer (NSCLC) after resection.Methods Clinical data of 131 NSCLC patients who underwent resection were reviewed and divided into chemotherapy group (86 cases) and non-chemotherapy group (45 cases) according to the treatment method.Survival rate was calculated by Kaplan-Meier method.The prognosis was analyzed by Cox proportional hazards model.Results The median survival time (MST) of squamous cell carcinoma (76 cases),bronchial alveolar cell carcinoma( 8 cases),adenocarcinoma( 35 cases ),adenosquamous carcinoma (12 cases) was 60,54,34,24 months respectively (P＜0.05).For the patients of stage Ⅰ B,the MST of chemotherapy group and non-chemotherapy group was 75 and 76 months respectively(P ＞ 0.05 ).Multivariate analysis showed that tumor size,T stage,N stage,chemotherapy were independent prognostic factors (P =0.080,0.002,0.000,0.029).Conclusions Squamous cell carcinoma and bronchial alveolar cell carcinoma have better prognosis than adenocarcinoma,adenosquamous carcinoma.For the patients of stage Ⅰ B,the survival time can't be prolonged through platinum-based chemotherapy.Tumor size,T stage,N stage,chemotherapy are independent prognostic factors.
