中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2012年
9期
1175-1178
,共4页
代谢综合征X/治疗%运动疗法
代謝綜閤徵X/治療%運動療法
대사종합정X/치료%운동요법
Metabolic syndrome X/therapy%Exercise therapy
目的 观察长期规律有氧运动对代谢综合征(MS)患者血清瘦素、白介素-18(IL-18)、C反应蛋白(CRP)、可溶性细胞间黏附因子-1(sICAM-1)及胰岛素抵抗指数(HOMA-IR)的影响,并初步探讨有氧运动的作用机制.方法 入选40例平时缺乏运动的MS患者,分层随机抽样法分为运动干预组及非诺贝特组,运动干预组进行无氧阈心率水平运动,5次/周,30 min/次；非诺贝特组口服非诺贝特胶囊200 mg/d.各组干预12周,干预前后采用ELISA法测定血清瘦素、IL-18、CRP、sICAM-1水平.另选20例健康体检者作为正常对照组.结果 MS患者血清瘦素[(26.04±9.07) ng/ml vs(8.32 ±2.94)ng/ml,t=12.72,P＜0.01]、IL-18[(308.27±50.39) pg/ml vs (230.60±29.15) pg/ml,t=6.41,P ＜0.01]、CRP[ (2.65±0.57) ng/ml vs( 1.26±0.23) ng/ml,t=9.69,P＜0.01]、sI-CAM-1[ (331.89 ±60.08) ng/ml vs (246.43 ±39.32) ng/ml,t=5.98,P＜0.01]及HOMA-IR(4.38±2.06 vs 2.12 ±0.50,t=4.81,P＜0.01)等指标明显高于健康人.经12周运动干预后,MS患者瘦素[( 26.38±10.85) ng/ml vs( 19.63±6.27) ng/ml,t=2.22,P＜0.05]、IL-18[ (309.40 ±49.77) pg/ml vs( 291.80±39.21) pg/m1,t =2.33,P＜0.05]、CRP[ (2.73 ±0.72)ng/ml vs (2.28 ±0.38)ng/ml,t =3.41,P ＜0.01]及sICAM-1[ (333.85±55.97) ng/ml vs (306.24±50.55) ng/ml,t=3.16,P＜0.01]水平及HOMA-IR(4.53 ±2.39 vs 2.89 ±0.69,t=2.87,P＜0.01)明显下降.结论 有氧运动是MS患者一种有效的治疗方法.运动治疗的作用机制可能与降低机体脂肪炎症因子水平,改善血管内皮功能,进一步改善胰岛素抵抗有关.
目的 觀察長期規律有氧運動對代謝綜閤徵(MS)患者血清瘦素、白介素-18(IL-18)、C反應蛋白(CRP)、可溶性細胞間黏附因子-1(sICAM-1)及胰島素牴抗指數(HOMA-IR)的影響,併初步探討有氧運動的作用機製.方法 入選40例平時缺乏運動的MS患者,分層隨機抽樣法分為運動榦預組及非諾貝特組,運動榦預組進行無氧閾心率水平運動,5次/週,30 min/次；非諾貝特組口服非諾貝特膠囊200 mg/d.各組榦預12週,榦預前後採用ELISA法測定血清瘦素、IL-18、CRP、sICAM-1水平.另選20例健康體檢者作為正常對照組.結果 MS患者血清瘦素[(26.04±9.07) ng/ml vs(8.32 ±2.94)ng/ml,t=12.72,P＜0.01]、IL-18[(308.27±50.39) pg/ml vs (230.60±29.15) pg/ml,t=6.41,P ＜0.01]、CRP[ (2.65±0.57) ng/ml vs( 1.26±0.23) ng/ml,t=9.69,P＜0.01]、sI-CAM-1[ (331.89 ±60.08) ng/ml vs (246.43 ±39.32) ng/ml,t=5.98,P＜0.01]及HOMA-IR(4.38±2.06 vs 2.12 ±0.50,t=4.81,P＜0.01)等指標明顯高于健康人.經12週運動榦預後,MS患者瘦素[( 26.38±10.85) ng/ml vs( 19.63±6.27) ng/ml,t=2.22,P＜0.05]、IL-18[ (309.40 ±49.77) pg/ml vs( 291.80±39.21) pg/m1,t =2.33,P＜0.05]、CRP[ (2.73 ±0.72)ng/ml vs (2.28 ±0.38)ng/ml,t =3.41,P ＜0.01]及sICAM-1[ (333.85±55.97) ng/ml vs (306.24±50.55) ng/ml,t=3.16,P＜0.01]水平及HOMA-IR(4.53 ±2.39 vs 2.89 ±0.69,t=2.87,P＜0.01)明顯下降.結論 有氧運動是MS患者一種有效的治療方法.運動治療的作用機製可能與降低機體脂肪炎癥因子水平,改善血管內皮功能,進一步改善胰島素牴抗有關.
목적 관찰장기규률유양운동대대사종합정(MS)환자혈청수소、백개소-18(IL-18)、C반응단백(CRP)、가용성세포간점부인자-1(sICAM-1)급이도소저항지수(HOMA-IR)적영향,병초보탐토유양운동적작용궤제.방법 입선40례평시결핍운동적MS환자,분층수궤추양법분위운동간예조급비낙패특조,운동간예조진행무양역심솔수평운동,5차/주,30 min/차；비낙패특조구복비낙패특효낭200 mg/d.각조간예12주,간예전후채용ELISA법측정혈청수소、IL-18、CRP、sICAM-1수평.령선20례건강체검자작위정상대조조.결과 MS환자혈청수소[(26.04±9.07) ng/ml vs(8.32 ±2.94)ng/ml,t=12.72,P＜0.01]、IL-18[(308.27±50.39) pg/ml vs (230.60±29.15) pg/ml,t=6.41,P ＜0.01]、CRP[ (2.65±0.57) ng/ml vs( 1.26±0.23) ng/ml,t=9.69,P＜0.01]、sI-CAM-1[ (331.89 ±60.08) ng/ml vs (246.43 ±39.32) ng/ml,t=5.98,P＜0.01]급HOMA-IR(4.38±2.06 vs 2.12 ±0.50,t=4.81,P＜0.01)등지표명현고우건강인.경12주운동간예후,MS환자수소[( 26.38±10.85) ng/ml vs( 19.63±6.27) ng/ml,t=2.22,P＜0.05]、IL-18[ (309.40 ±49.77) pg/ml vs( 291.80±39.21) pg/m1,t =2.33,P＜0.05]、CRP[ (2.73 ±0.72)ng/ml vs (2.28 ±0.38)ng/ml,t =3.41,P ＜0.01]급sICAM-1[ (333.85±55.97) ng/ml vs (306.24±50.55) ng/ml,t=3.16,P＜0.01]수평급HOMA-IR(4.53 ±2.39 vs 2.89 ±0.69,t=2.87,P＜0.01)명현하강.결론 유양운동시MS환자일충유효적치료방법.운동치료적작용궤제가능여강저궤체지방염증인자수평,개선혈관내피공능,진일보개선이도소저항유관.
Objective To explore the effect of aerobic exercise on serum leptin,interleukin-18 (IL-18),soluble intercellular adhesion molecule-1 (sICAM-1),C reaction protein (CRP) concentration,and homeostasis model assessment insulin resistance (HOMA-IR) of patients with metabolic syndrome ( MS),and to explore its mechanism.Methods Forty sedentary patients with MS were randomly divided into exercise group and fenofibrate group.Patients in exercise group were trained at anaerobic threshold intensity (30 min/times) for 12 weeks (5 times/wk).Patients in fenofibrate group were treated with fenofibrate 200 mg every night.Serum leptin,IL-18,CRP,and sICAM-1 concentration were measured by enzyme linked immunosorbent assay (ELISA).Twenty healthy subjects were selected as the control group.Results Serum concentration of leptin [ ( 26.04 ± 9.07 ) ng/ml vs ( 8.32 ± 2.94 ) ng/ml,t =12.72,P ＜0.01 ],IL-18[ (308.27 ±50.39)pg/ml vs (230.60 ±29.15)pg/ml,t =6.41,P ＜0.01 ],CRP[ (2.65±0.57)ng/ml vs ( 1.26 ±0.23) ng/ml,t =9.69,P ＜0.01 ],sICAM-1 [ (331.89 ±60.08) ng/ml vs (246.43±39.32)ng/ml,t =5.98,P ＜0.01],and HOMA-IR(4.38 ±2.06 vs 2.12 ± 0.50,t =4.81,P ＜ 0.01 ) of patients with MS were significantly increased compared to the control.Serum concentration of leptin[(26.38±10.85)ng/ml vs (19.63 ±6.27)ng/ml,t =2.22,P ＜0.05],IL-18[(309.40 ±49.77)pg/ml vs (291.80 ±39.21)pg/ml,t =2.33,P ＜0.05],CRP[ (2.73 ±0.72)ng/ml vs (2.28 ±0.38)ng/ml,t =3.41,P ＜0.01 ],sICAM-1 [ (333.85 ±55.97) ng/ml vs (306.24 ±50.55) ng/ml,t =3.16,P ＜0.01],and HOMA-IR(4.53 ±2.39 vs 2.89 ±0.69,t =2.87,P ＜0.01 ) were significantly decreased after training for 12 weeks.Conclusions Aerobic exercise is one of the effective treatments of patients with MS.Its underlying mechanism may be associated with reduction of serum inflammatory adipokine concentration,and improvement of vascular endothelial function and insulin resistance.
