CAJ | 학술논문

目的探讨绿原酸对糖尿病大鼠肾脏氧化及抗氧化系统的影响.方法将36只大鼠随机分成N组(正常组)、DM组(糖尿病组)及CA组(绿原酸干预组).DM组和CA组造糖尿痛模型,分别给予腹腔注射生理盐水和绿原酸,饲养10周后,测定血糖、肾脏重量、体重变化,肾皮质超氧化物歧化酶(SOD)、谷胱甘肽过氧化酶(GSH-PX)、丙二醛(MDA)含量及尿微量白蛋白排泄率(UAER).结果与DM组大鼠相比,CA组大鼠血糖无明显差别,而肾重、体重明显增加,肾皮质SOD、GSH-PX活性明显上升,MDA含量及UAER则明显减少(均P<0.05).结论绿原酸有改善糖尿病大鼠的一般状况,提高抗氧化能力,抑制氧化应激.减少尿蛋白的作用.
목적 탐토록원산대당뇨병대서신장양화급항양화계통적영향.방법 장36지대서수궤분성N조(정상조)、DM조(당뇨병조)급CA조(록원산간예조).DM조화CA조조당뇨통모형,분별급여복강주사생리염수화록원산,사양10주후,측정혈당、신장중량、체중변화,신피질초양화물기화매(SOD)、곡광감태과양화매(GSH-PX)、병이철(MDA)함량급뇨미량백단백배설솔(UAER).결과 여DM조대서상비,CA조대서혈당무명현차별,이신중、체중명현증가,신피질SOD、GSH-PX활성명현상승,MDA함량급UAER칙명현감소(균P<0.05).결론 록원산유개선당뇨병대서적일반상황,제고항양화능력,억제양화응격.감소뇨단백적작용.
Objective To investigate the effect of Chlorogenic acid on oxidative and antioxidative system of kidney in diabetic rats.Methods 36 rats were randomly divided into three groups:normal group(N group),diabetes mellitus group(DM group)and diabetes group treated with chlorogenic acid(CA group).Ten weeks later,blood glu-cose,weight of body and kidney ,the activity of superoxide dismutase(SOD)and glutathione peroxidase(GSH-PX)lipidperoxidation(MDA),urinary albumin excretory rate(UARE)in renal tissue were measured.Results The levels of blood glucose were not significantly different between DM group and CA group,but the weight of rats and kid-ney and the activity of SOD and GSH-PX in CA group were higher than DM group,and MDA and UAER of CA group were lower(P<0.05 for each).Conclusion Chlorogenic acid effective in improving the antioxidativity,inhibiting oxidative stress and decreasing urinary albumin.