CAJ | 학술논문

目的探讨Survivin蛋白在食管癌组织中的表达和,临床意义.方法采用免疫组化方法检测61例食管鳞癌手术切除标本及26例癌旁组织的Survivin蛋白表达情况.结果食管鳞癌组织Survivin阳性表达率为60.7%(37/61);Survivin表达与肿瘤病理分级、浸润深度、临床分期、淋巴结转移和患者生存期有明显相关性(均P<0.01).结论 Survivin的表达可以作为判断食管癌恶性潜能的重要生物学指标,对于临床选择高危复发病例给予积极治疗、提高预后水平具有重要意义.
목적 탐토Survivin단백재식관암조직중적표체화,림상의의.방법채용면역조화방법검측61례식관린암수술절제표본급26례암방조직적Survivin단백표체정황.결과식관린암조직Survivin양성표체솔위60.7%(37/61);Survivin표체여종류병리분급、침윤심도、림상분기、림파결전이화환자생존기유명현상관성(균P<0.01).결론 Survivin적표체가이작위판단식관암악성잠능적중요생물학지표,대우림상선택고위복발병례급여적겁치료、제고예후수평구유중요의의.
Objective To investigate the expression and clinical significance of Survivin in esophageal car-cinoma.Methods Survivin expression was detected by immunohistochemistry in 61 cases of esophageal squamous carcinoma tissues and 26 tumor-adjacent normal tissues.Results The positive Survivin expression rate was 60.7% (37/61)in tumor tissues.The expression of Survivin was significantly correlated with the tumor grading,infiltration, lymph node metastasis and the survival(P<0.01).Conclusion Survivin may be an important marker for tumor di-agnosis and it is of great important to the active treatment of high-risk patients and to increasing of prognosis values.