国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2010年
4期
249-252
,共4页
Th17细胞%IL-17%自身免疫性疾病
Th17細胞%IL-17%自身免疫性疾病
Th17세포%IL-17%자신면역성질병
Th17 cell%Interleukin-17%Autoimmune diseases
Th17细胞是最近发现的一种在分化和功能上均不同于Th1和Th2的新型CD4+T细胞亚群.该群细胞以主要分泌细胞因子IL-17而得名.IL-6、TGF-β、IL-21及IL-23等对Th17细胞的分化调控发挥重要作用.研究表明,Th17细胞可参与多种自身免疫性疾病的发生、发展与转归.
Th17細胞是最近髮現的一種在分化和功能上均不同于Th1和Th2的新型CD4+T細胞亞群.該群細胞以主要分泌細胞因子IL-17而得名.IL-6、TGF-β、IL-21及IL-23等對Th17細胞的分化調控髮揮重要作用.研究錶明,Th17細胞可參與多種自身免疫性疾病的髮生、髮展與轉歸.
Th17세포시최근발현적일충재분화화공능상균불동우Th1화Th2적신형CD4+T세포아군.해군세포이주요분비세포인자IL-17이득명.IL-6、TGF-β、IL-21급IL-23등대Th17세포적분화조공발휘중요작용.연구표명,Th17세포가삼여다충자신면역성질병적발생、발전여전귀.
The latest revealed Th17 cell belongs to a new subgroup of CD4+T cell which differs from Th1 and Th2 on differentiation and function.The cell is so named because of its characteristic of mainly excreting cytokine IL-17.Cytokine IL-6,TGF-β,IL-21 and IL-23 all of them play important roles in differentiation and regulation of Th17 cell.Studies showed that Th17 cell can participate in the development of mutiple autoimmne diseases.
