CAJ | 학술논문

白介素23(IL-23)是一个由IL-23p19和IL-12p40组成的异二聚体细胞因子,属IL-12炎症因子家族成员.它广泛参与体内免疫过程,调节免疫细胞的分化发育、增殖及炎症反应.IL-23受体复合物由IL-12R131和IL-23R两个亚基构成.IL-23受体的致病作用与通过IL-23-信号转导和转录激活因子3-Thl7-IL-17途径介导免疫异常有关.在治疗慢性炎症方面,以IL-23配体或受体为靶点的单克隆抗体已取得初步成效.对IL-23/IL-23受体基因及其致病途径的深入研究,将为寻找更多慢性炎症治疗的靶点提供有力依据.随着先进的分子生物学以及其他技术的应用,对IL-23/IL-23受体的作用将会有更多更深入的认识,为一些相关疾病的发病机制和治疗手段的研究提供理论基础.
백개소23(IL-23)시일개유IL-23p19화IL-12p40조성적이이취체세포인자,속IL-12염증인자가족성원.타엄범삼여체내면역과정,조절면역세포적분화발육、증식급염증반응.IL-23수체복합물유IL-12R131화IL-23R량개아기구성.IL-23수체적치병작용여통과IL-23-신호전도화전록격활인자3-Thl7-IL-17도경개도면역이상유관.재치료만성염증방면,이IL-23배체혹수체위파점적단극륭항체이취득초보성효.대IL-23/IL-23수체기인급기치병도경적심입연구,장위심조경다만성염증치료적파점제공유력의거.수착선진적분자생물학이급기타기술적응용,대IL-23/IL-23수체적작용장회유경다경심입적인식,위일사상관질병적발병궤제화치료수단적연구제공이론기출.
Interleukin-23(IL-23) is a member of IL-12 family,a heterodimer composed of IL-23p19 and IL-12p40.It extensively participates in immunologic process in vivo, regulates differentiation, proliferation and inflammatory reaction of immunocyte.IL-23 receptor compound is composed of IL-12Rβ1 and IL-23R.The pathogenic mechanism of IL-23 receptor to inflammation is associated with the disordered immune response mediated by IL-23-signal transducer and activators of transcription-3-helper T cell-17-IL-17 pathway.Monoclonal antibodies targeting to the ligands or receptors of IL-23 have been prospective in the biotherapy of inflammation.Further study on the IL-23/IL-23 receptor genes and their functions in the pathogenesis of inflammation will help us find more treatment targets.With advanced molecular biology and other technology, more and more recognition of IL-23/IL-23 receptor will appear, which can provide rationale to pathogenesy and treatment of correlated diseases.