CAJ | 학술논문

目的观察老年原发性高血压病患者血压变异性(BPV)对心脏结构和肾功能损伤影响.方法根据夜间血压下降率将患者分为年龄、性别相匹配的两组,夜间血压下降率<10%为非杓型组,≥10%为杓型组.应用24小时动态血压监测和超声心动图方法观察并比较200例原发性高血压病患者的动态血压节律及心脏结构、肾功能的特点.结果非杓型组24h收缩压、24h舒张压、夜间收缩压、夜间舒张压明显高于杓型组,非杓型组夜间血压变异显著高于杓型组,非杓型组左室重量指数高于杓型组,肾功能尿系列蛋白检出率非杓型组均显著高于杓型组.结论非杓型组高血压病人的血压节律类型较杓型组者更易导致左心室肥厚及肾功能减退.
목적 관찰노년원발성고혈압병환자혈압변이성(BPV)대심장결구화신공능손상영향.방법 근거야간혈압하강솔장환자분위년령、성별상필배적량조,야간혈압하강솔<10%위비표형조,≥10%위표형조.응용24소시동태혈압감측화초성심동도방법 관찰병비교200례원발성고혈압병환자적동태혈압절률급심장결구、신공능적특점.결과 비표형조24h수축압、24h서장압、야간수축압、야간서장압명현고우표형조,비표형조야간혈압변이현저고우표형조,비표형조좌실중량지수고우표형조,신공능뇨계렬단백검출솔비표형조균현저고우표형조.결론 비표형조고혈압병인적혈압절률류형교표형조자경역도치좌심실비후급신공능감퇴.
Objective To investigate the influence of blood pressure variability (BPV) on cardiac structure and renal injury in patients with senile essential hypertension. Methods Two hundred patients with essential hypertension were divided into two groups according to decreasing rate of blood pressure in night. The patients with <10% decreasing rate of blood pressure were allocated into non-dipper group and ≥10% into dipper group, which were matched in age and gender. Ambulatory blood pressure monitoring and echocardiography were performed in all of them. Results 24 h SBP、24 h DBP、night SBP (nSBP) and night DBP (nDBP) were significantly higher in non-dipper group than those in dipper group. Night BPV was significantly higher in non-dipper group than those in dipper group. Left ventricular mass index was higher in non-dipper group than those in dipper group. Most of finding rate of a series microproteinuria was significantly higher in non-dipper group than those in dipper group. Conclusions Non-dipper circadian rhythm could induce the decrease of renal function and increase of left ventricular hypertrophy in patients with essential hypertension.