CAJ | 학술논문

目的用双生子研究方法对成年人血尿酸的遗传度进行估计.方法从青岛双生子库募集成年双生子.测量身高、体重和血尿酸.相同性别的双生子采用16个多态标记进行卵型鉴定.通过校正年龄、性别和BMI,来构建结构方程模型估计遗传度.结果共收集687对双生子数据,其中同卵双生子420对,异卵双生子267对.经平方根转换后,男性血尿酸水平(17.47±1.91)略高于女性(15.22±1.70)(P＜0.0001),通过校正年龄、性别和BMI后双生子血尿酸的组内相关系数分别为,同卵双生子0.70、异卵双生子0.40.运用性别限制模型进行拟合,最佳模型AE模型,加性别遗传因素和特殊环境因素共同作用血尿酸的水平.血尿酸的遗传度为70.5%(95%CI:65.9～74.6),特殊环境因素占29.5%(95%CI:25.4～34.2).结论遗传因素是影响样本双生子血尿酸水平的主要因素.
목적 용쌍생자연구방법 대성년인혈뇨산적유전도진행고계.방법 종청도쌍생자고모집성년쌍생자.측량신고、체중화혈뇨산.상동성별적쌍생자채용16개다태표기진행란형감정.통과교정년령、성별화BMI,래구건결구방정모형고계유전도.결과 공수집687대쌍생자수거,기중동란쌍생자420대,이란쌍생자267대.경평방근전환후,남성혈뇨산수평(17.47±1.91)략고우녀성(15.22±1.70)(P＜0.0001),통과교정년령、성별화BMI후쌍생자혈뇨산적조내상관계수분별위,동란쌍생자0.70、이란쌍생자0.40.운용성별한제모형진행의합,최가모형AE모형,가성별유전인소화특수배경인소공동작용혈뇨산적수평.혈뇨산적유전도위70.5%(95%CI:65.9～74.6),특수배경인소점29.5%(95%CI:25.4～34.2).결론 유전인소시영향양본쌍생자혈뇨산수평적주요인소.
Objective To assess the heritability of serum uric acid in adult,using the classic twin design.Methods Adult Twins were recruited from the Qingdao Twin Registry.Uric acid,height,weight were measured.Zygosity in all the same-sex twin pairs was determined by 16 polymorphic markers.Heritability was assessed by structural equation models,with age,gender and body mass index(BMI) included as covariates.Results In total,687 twin pairs were available for data analyses,including 420 pairs of monozygotic and 267 pairs of dizygotic twins.After logarithm transformed,uric acid in males ( 17.47±1.91 ) was significantly higher than in females ( 15.22±1.70,P＜0.0001 ).After adjustment on age,sex and BMI,intraclass correlations for uric acid were 0.70 for monozygotic twins and 0.40 for dizygotic twins.The sex-limitation AE model,combining additive genetic and unique environmental factors,could produce the best fit for the data.Heritability estimate for uric acid was 70.5% (95% CI:65.9-74.6),with the proportion of unique environmental effects as 29.5%(95%CI:25.4-34.2).Conclusion Additive genetic effects appeared to be the major contributor to the variation of uric acid in this twins sample being studied.