CAJ | 학술논문

目的通过研究依达拉奉对重型颅脑损伤患者急性期外周血神经元特异性烯醇化酶(NSE)表达的影响,进一步研究依达拉奉对重型颅脑损伤患者急性期的治疗效果.方法将入选的60例重型颅脑损伤患者随机分为治疗组和对照组,每组各30例.治疗组在基础治疗的同时加用依达拉奉治疗,对照组除不加用依达拉奉外其他治疗方法同治疗组.两组治疗前、治疗后1、3、5、7 d清晨7时抽取外周静脉血测NSE水平.结果治疗组和对照组治疗前NSE水平分别为(48.73±30.46)μg/L和(40.86±22.05)μg/L,两组间比较差异无统计学意义(P＞0.05),治疗后3、5、7 d,两组NSE水平分别为(34.16±15.08)、(29.86±12.61)、(29.93±14.77)μg/L和(27.42±10.07)、(22.33±8.93)、(21.17±9.67)μg/L,组内和组间比较差异均有统计学意义(P＜0.05或＜0.01).而且随着治疗时间的延长,NSE水平进行性下降.两组用药期间未见有任何药物不良反应.结论依达拉奉对重型颅脑损伤患者急性期外周血NSE表达的影响非常显著,对重型颅脑损伤患者急性期有较好的治疗效果,且用药安全,不良反应少.
목적 통과연구의체랍봉대중형로뇌손상환자급성기외주혈신경원특이성희순화매(NSE)표체적영향,진일보연구의체랍봉대중형로뇌손상환자급성기적치료효과.방법 장입선적60례중형로뇌손상환자수궤분위치료조화대조조,매조각30례.치료조재기출치료적동시가용의체랍봉치료,대조조제불가용의체랍봉외기타치료방법동치료조.량조치료전、치료후1、3、5、7 d청신7시추취외주정맥혈측NSE수평.결과 치료조화대조조치료전NSE수평분별위(48.73±30.46)μg/L화(40.86±22.05)μg/L,량조간비교차이무통계학의의(P＞0.05),치료후3、5、7 d,량조NSE수평분별위(34.16±15.08)、(29.86±12.61)、(29.93±14.77)μg/L화(27.42±10.07)、(22.33±8.93)、(21.17±9.67)μg/L,조내화조간비교차이균유통계학의의(P＜0.05혹＜0.01).이차수착치료시간적연장,NSE수평진행성하강.량조용약기간미견유임하약물불량반응.결론 의체랍봉대중형로뇌손상환자급성기외주혈NSE표체적영향비상현저,대중형로뇌손상환자급성기유교호적치료효과,차용약안전,불량반응소.
Objecfive To study the influence of edaravone therapy on semm levels of neuronspecific enolase (NSE)in the patients of severe brain trauma and assess the therapic effect of edaravone.Method Sixty patients of severe brain trauma were randomly assigned into the treatment group(n=30)and the control group(n=30).Besides the routine treatment in both groups.edaravone Was only used in the treatment group.NSE levels were measured in the two groups before treatment and at 1st,3rd,5th,7th day after treatment.Results NSE levels before treatment in treatment group and control group were(48.73±30.46)μg/L and (40.86±22.05)μg/L,respectively,there Was no statistical significance between two groups.NSE levels after treatment at 3rd,5th,7th day in the two groups were(34.16±15.08),(29.86±12.61),(29.93±14.77)μg/L and (27.42±10.07),(22.33±8.93),(21.17±9.67)μg/L,respectively,there were statistical significances between two groups and in the same group (P＜ 0.05 or ＜ 0.01 ). With the time of therapy extended,NSE levels declined progressively. There were no significant adverse drug reactions during the treatment period. Conclusions The influence of edaravone therapy on serum levels of NSE in the patients of severe brain trauma is significant,edaravone for patients with severe brain trauma has a better curative effect ,medication safety,and fewer adverse drug reactions during acute phase.