CAJ | 학술논문

目的探讨肿瘤坏死因子-α(TNF-α)基因308、238位点多态性与尘肺易感关系.方法检索中外数据库于1994年1月至2010年12月公开发表的文献,共检索到关于TNF-α基因308、238位点多态性与尘肺发病风险相关的病例-对照研究18篇.对文献进行Meta分析,并按尘肺类型和种族进行分层分析,计算合并OR值(95%CI).结果共纳入文献11篇,其中TNF-α基因308位点相关研究10篇,累计病例组1408例,对照组1639名;分析显示,携带精氨酸(Arg)/Arg、谷氨酰胺(Gln)/Arg、Gln/Arg+Arg/Arg基因型个体与携带Gln/Gln基因型个体相比,尘肺发病风险分别为其1.89(95%CI:1.10～3.24)、1.53(95%CI:1.25～1.87)、1.56(95%CI:1.28～1.90)倍;分层分析显示,煤工人群中携带Arg/Arg、Ch/Arg、Gln/Arg+Arg/Arg基因型的个体与携带Gln/Gln基因型者相比,尘肺发病风险分别为其2.29(95%CI:1.22～4.29)、1156(95%CI:1.20～2.03)、1.64(95%CI:1.28～2.11)倍;亚洲人群中携带Gln/Arg、Gln/Arg+Arg/Arg基因型个体与携带Gln/Gln基因型者相比,尘肺发病风险分别为其1.58(95%CI:1.28～1.95)、1.57(95%CI:1.28～1.94)倍.共有4篇TNF-α基因238位点相关研究,累计病例组391例,对照组391名;分析显示,携带Arg/Arg、Gln/Arg、Gln/Arg+Arg/Arg基因型个体与不携带者相比,尘肺发病风险分别为其6.03(95%CI:1.35～26.97)、1.87(95%CI:1.07～3.30)、2.36(95%CI:1.37～4.07)倍.结论 TNF-α基因308、238位点Arg/Arg、Gln/Arg+Gln/Arg+Arg/Arg基因型携带者易患尘肺.
목적 탐토종류배사인자-α(TNF-α)기인308、238위점다태성여진폐역감관계.방법 검색중외수거고우1994년1월지2010년12월공개발표적문헌,공검색도관우TNF-α기인308、238위점다태성여진폐발병풍험상관적병례-대조연구18편.대문헌진행Meta분석,병안진폐류형화충족진행분층분석,계산합병OR치(95%CI).결과 공납입문헌11편,기중TNF-α기인308위점상관연구10편,루계병례조1408례,대조조1639명;분석현시,휴대정안산(Arg)/Arg、곡안선알(Gln)/Arg、Gln/Arg+Arg/Arg기인형개체여휴대Gln/Gln기인형개체상비,진폐발병풍험분별위기1.89(95%CI:1.10～3.24)、1.53(95%CI:1.25～1.87)、1.56(95%CI:1.28～1.90)배;분층분석현시,매공인군중휴대Arg/Arg、Ch/Arg、Gln/Arg+Arg/Arg기인형적개체여휴대Gln/Gln기인형자상비,진폐발병풍험분별위기2.29(95%CI:1.22～4.29)、1156(95%CI:1.20～2.03)、1.64(95%CI:1.28～2.11)배;아주인군중휴대Gln/Arg、Gln/Arg+Arg/Arg기인형개체여휴대Gln/Gln기인형자상비,진폐발병풍험분별위기1.58(95%CI:1.28～1.95)、1.57(95%CI:1.28～1.94)배.공유4편TNF-α기인238위점상관연구,루계병례조391례,대조조391명;분석현시,휴대Arg/Arg、Gln/Arg、Gln/Arg+Arg/Arg기인형개체여불휴대자상비,진폐발병풍험분별위기6.03(95%CI:1.35～26.97)、1.87(95%CI:1.07～3.30)、2.36(95%CI:1.37～4.07)배.결론 TNF-α기인308、238위점Arg/Arg、Gln/Arg+Gln/Arg+Arg/Arg기인형휴대자역환진폐.
Objective To explore the relationship between the polymorphism of TNF-α gene 308,238 locus and the susceptibility to pneumoconiosis.Methods Eighteen published cage-control studies about TNF-α gene 308,238 locus polymorphism and pneumoconiosis susceptibility were searched out from sino-foreign databases from January 1994 to December 2010.Meta-analysis was applied on the published research to calculate the pooled OR value(95%CI)and stratifiedly analyze the types and species of pneumoconiosis.Results Eleven of the published research articles were selected into the analysis.including 10 research focusing on TNF-α gene 308 locus,with 1408 cases and 1639 controls in total.The meta-analysis showed that comparing with Gln/Gln carriers,Arg/Arg,Arg/Gln,Gln/Arg+Arg/Arg carriers were 1.89-fold (95%CI:1.10-3.24),1.53-fold(95%CI:1.25-1.87),and 1.56-fold(95%CI:1.28-1.90)more susceptible to pneumoconiosis,respectively.The stratified analysis showed that among coal workers,the TNF-α gene 308 locus Arg/Arg,Arg/Gln,Gln/Arg+Arg/Arg carriers were separately 2.29-fold(95%CI:1. 22-4.29),1.56-fold(95%CI:1.20-2.03),1.64-fold(95%CI:1.28-2.11)more susceptible to pneumeconiosis than Gln/Gln carriers;and among Asian people,the TNF-α gene 308 locus Gln/Arg,Gln/Arg+Arg/Arg carriers were separately 1.58-fold(95%CI:1.28-1.95)and 1.57.fold(95%CI:1.28-1.94)more susceptible to pneumoconiosis than the Gln/Gln carriers.Four case-control research focus on the study of TNF-αgene 238 locus.including 391 cases and 391 controls in total. The analysis showed that comparing with the non-carriers,TNF-α gene 238 locus Arg/Arg,Arg/Gln,Gln/Arg+Arg/Arg carriers were 6.03-fold(95%CI:1.35-26.97),1.87.fold(95%CI:1.07-3.30)and 2.36-fold(95%CI:1.37-4.07)more susceptible to pneumoconiosis.Conclusion TNF-α gene 308,238 locus Arg/Arg,Gln/Arg,Gln/Arg+Arg/Arg carriers are more susceptible to pneumoconiosis.