CAJ | 학술논문

目的采用RP-HPLC法考察了黄芩苷水溶液的稳定性.方法采用经典恒温加速试验考察了温度对黄芩苷水溶液的影响,并测定了黄芩苷水溶液的最稳定pH.结果黄芩苷水溶液损失10%所需要的时间仅为18.1 h,降解活化能为79.1kJ·moL-1.黄芩苷的最稳定pH值采用实测值为4.28.结论黄芩苷水溶液受温度和pH的影响很大,因此在生产过程中,应尽可能保持低温,并调节溶液pH值使接近黄芩苷的最稳定pH.
목적채용RP-HPLC법고찰료황금감수용액적은정성.방법채용경전항온가속시험고찰료온도대황금감수용액적영향,병측정료황금감수용액적최은정pH.결과황금감수용액손실10%소수요적시간부위18.1 h,강해활화능위79.1kJ·moL-1.황금감적최은정pH치채용실측치위4.28.결론황금감수용액수온도화pH적영향흔대,인차재생산과정중,응진가능보지저온,병조절용액pH치사접근황금감적최은정pH.
Aim In the present study a RP-HPLC method was developed and validated to investigate the stability of baicalin aqueous solution. Methods The influences of temperature and pH on the stability of baicalin aqueous solution were investigated by classic homoiothermic acceleration test, and the pH for the most stable solution was determined. Results The time when baicalin suffered 10% loss was found to be 18.1 h, and the degradation activation energy of baicalin was 79.1 kJ·moL- 1. The pH at which baicalin is most stable is 4.28. Conclusion The temperature should be kept at a lower level and the pH should be adjusted to near that for the most stable solution in the production of baicalin preparations.