时珍国医国药
時珍國醫國藥
시진국의국약
LISHIZHEN MEDICINE AND MATERIA MEDICA RESEARCH
2010年
2期
278-279
,共2页
张小玲%肖胜军%高雅%容明智%张可锋%沈洁%陈力锋%朱华
張小玲%肖勝軍%高雅%容明智%張可鋒%瀋潔%陳力鋒%硃華
장소령%초성군%고아%용명지%장가봉%침길%진력봉%주화
狗肝菜多糖%急性肝损伤%保肝
狗肝菜多糖%急性肝損傷%保肝
구간채다당%급성간손상%보간
Dicliptera chinensis polysaccharide%Acute liver injury%Liver protection
目的 观察狗肝菜多糖对D-半乳糖胺所致大鼠急性肝损伤的影响.方法 建立D-半乳糖胺(D-GalN)诱发的大鼠急性肝损伤模型,不同浓度狗肝菜多糖干预后,测定动物血清ALT、AST.肝组织常规制片及HE染色观察组织病理学改变.结果 狗肝菜多糖能使肝损伤动物血清ALT、AST水平显著降低.组织病理学检测发现狗肝菜多糖处理后肝组织损害程度降低 .结论 狗肝菜多糖对D-半乳糖胺所致大鼠急性肝损伤具有保护作用.
目的 觀察狗肝菜多糖對D-半乳糖胺所緻大鼠急性肝損傷的影響.方法 建立D-半乳糖胺(D-GalN)誘髮的大鼠急性肝損傷模型,不同濃度狗肝菜多糖榦預後,測定動物血清ALT、AST.肝組織常規製片及HE染色觀察組織病理學改變.結果 狗肝菜多糖能使肝損傷動物血清ALT、AST水平顯著降低.組織病理學檢測髮現狗肝菜多糖處理後肝組織損害程度降低 .結論 狗肝菜多糖對D-半乳糖胺所緻大鼠急性肝損傷具有保護作用.
목적 관찰구간채다당대D-반유당알소치대서급성간손상적영향.방법 건립D-반유당알(D-GalN)유발적대서급성간손상모형,불동농도구간채다당간예후,측정동물혈청ALT、AST.간조직상규제편급HE염색관찰조직병이학개변.결과 구간채다당능사간손상동물혈청ALT、AST수평현저강저.조직병이학검측발현구간채다당처리후간조직손해정도강저 .결론 구간채다당대D-반유당알소치대서급성간손상구유보호작용.
Objective To observe the effect of the Dicliptera chinensis polysaccharide on the rat acute liver injury induced by D-GalN.Methods D-GalN-induced acute liver injury model was esablished in rats. After administrated different dose of Dicliptera chinensis polysaccharide, rat serum was coneated for detection of the contents of ALT, AST.HE staining was used to evaluate histopathological change of liver. Results Dicliptera chinensis polysaccharide could reduce the serum concents of ALT, AST,alleviate histopathological injury.Conclusion Dicliptera chinensis polysaccharide has protective effect on D-GalN-induced acute liver injury.
