中国全科医学
中國全科醫學
중국전과의학
CHINESE GENERAL PRACTICE
2010年
8期
888-890
,共3页
殷松楼%周冬梅%奚珏%庄玮%殷寒秋
慇鬆樓%週鼕梅%奚玨%莊瑋%慇寒鞦
은송루%주동매%해각%장위%은한추
糖尿病,2型%噻唑烷二酮类%吡格列酮%超氧化物歧化酶%谷胱甘肽过氧化物酶%丙二醛
糖尿病,2型%噻唑烷二酮類%吡格列酮%超氧化物歧化酶%穀胱甘肽過氧化物酶%丙二醛
당뇨병,2형%새서완이동류%필격렬동%초양화물기화매%곡광감태과양화물매%병이철
Diabetes mellitus,type 2%Thiazolidinediones%Pioglitazone%Superoxide dismutase%Glutathione peroxidase%Malondialdehyde
目的 探讨吡格列酮对2型糖尿病患者氧化应激的影响.方法 收集于本院就诊的2型糖尿病患者130例,随机分成对照组和吡格列酮组,每组65例.对照组给予门冬胰岛素30和二甲双胍控制血糖;吡格列酮组使用门冬胰岛素30、二甲双胍和吡格列酮(15 mg/d)降糖治疗,均治疗3个月.治疗前后检测并比较两组患者血清氧化应激指标:超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA).结果 治疗后吡格列酮组患者血清SOD、GSH-Px活性[(54±18)U/ml和(82±18)U/ml]较治疗前[(39±16)U/ml和(71±22)U/ml]显著升高,MDA水平[(2.6±1.7)nmol/ml]较治疗前[(3.8±2.3)nmol/ml]显著降低,差异有统计学意义(P＜0.05),且治疗后吡格列酮组上述3种指标与对照组[(42±18)U/ml、(73±19)U/ml和(3.5±1.8)nmol/ml]比较,差异有统计学意义(P＜0.01).结论 吡格列酮能提高2型糖尿病患者血清SOD和GSH-Px活性,降低MDA水平,而且吡格列酮的这种作用不依赖于降糖作用.
目的 探討吡格列酮對2型糖尿病患者氧化應激的影響.方法 收集于本院就診的2型糖尿病患者130例,隨機分成對照組和吡格列酮組,每組65例.對照組給予門鼕胰島素30和二甲雙胍控製血糖;吡格列酮組使用門鼕胰島素30、二甲雙胍和吡格列酮(15 mg/d)降糖治療,均治療3箇月.治療前後檢測併比較兩組患者血清氧化應激指標:超氧化物歧化酶(SOD)、穀胱甘肽過氧化物酶(GSH-Px)、丙二醛(MDA).結果 治療後吡格列酮組患者血清SOD、GSH-Px活性[(54±18)U/ml和(82±18)U/ml]較治療前[(39±16)U/ml和(71±22)U/ml]顯著升高,MDA水平[(2.6±1.7)nmol/ml]較治療前[(3.8±2.3)nmol/ml]顯著降低,差異有統計學意義(P＜0.05),且治療後吡格列酮組上述3種指標與對照組[(42±18)U/ml、(73±19)U/ml和(3.5±1.8)nmol/ml]比較,差異有統計學意義(P＜0.01).結論 吡格列酮能提高2型糖尿病患者血清SOD和GSH-Px活性,降低MDA水平,而且吡格列酮的這種作用不依賴于降糖作用.
목적 탐토필격렬동대2형당뇨병환자양화응격적영향.방법 수집우본원취진적2형당뇨병환자130례,수궤분성대조조화필격렬동조,매조65례.대조조급여문동이도소30화이갑쌍고공제혈당;필격렬동조사용문동이도소30、이갑쌍고화필격렬동(15 mg/d)강당치료,균치료3개월.치료전후검측병비교량조환자혈청양화응격지표:초양화물기화매(SOD)、곡광감태과양화물매(GSH-Px)、병이철(MDA).결과 치료후필격렬동조환자혈청SOD、GSH-Px활성[(54±18)U/ml화(82±18)U/ml]교치료전[(39±16)U/ml화(71±22)U/ml]현저승고,MDA수평[(2.6±1.7)nmol/ml]교치료전[(3.8±2.3)nmol/ml]현저강저,차이유통계학의의(P＜0.05),차치료후필격렬동조상술3충지표여대조조[(42±18)U/ml、(73±19)U/ml화(3.5±1.8)nmol/ml]비교,차이유통계학의의(P＜0.01).결론 필격렬동능제고2형당뇨병환자혈청SOD화GSH-Px활성,강저MDA수평,이차필격렬동적저충작용불의뢰우강당작용.
Objective To investigate the effects of pioglitazone on oxidative stress in T2DM.Methods One hundred thirty T2DM patients were randomized into groups control and Pioglitazone,65 in each.Control group were given insulin aspart 30 and metformin to control blood glucose;Pioglitazone group insulin aspart 30,metformin and Pioglitazone (15 mg/d) for hypoglycemic treatment.The treatments lasted 3 months.Serum oxidative stress indicators such as superoxide dismutase (SOD),glutathione peroxidase (GSH-Px) and melondialdehyde (MDA) were determined before and after treatment.Results In Pioglitazone group,activities of SOD and GSH-Px were significantly higher after treatment (54±18 U/ml,82±18 U/ml,respectively) than before (39±16 U/ml,71±22 U/ml,respectively),MDA level lower (2.6±1.7nmol/ml,3.8±2.3 nmol/ml,respectively),the difference was significant (P＜0.05).Pioglitazone group was different from control in the above 3 indicators (42±18 U/ml,73±19 U/ml,3.5±1.8 nmol/ml,respectively) after treatment,the difference was significant (P＜0.01).Conclusion Pioglitazone can improve the activities of SOD,GSH-Px and reduce MDA level,not depending on hypoglycemic effect.
