国际皮肤性病学杂志
國際皮膚性病學雜誌
국제피부성병학잡지
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
2012年
5期
354-356
,共3页
臭汗症%因果律%研究
臭汗癥%因果律%研究
취한증%인과률%연구
Bromidrosis%Causality%Research
腋臭的病因和发病机制至今尚在研究中.ApoD蛋白可能是腋臭发生分子机制中的核心蛋白,研究表明,顶泌汗腺的分泌物E-3M2H可能借助ApoD蛋白为载体,从体表散发出典型的辛辣气味.ApoD基因自身及其调控因素的差异可能是疾病发生的重要原因之一.在上述过程中,微生物的调控、雄激素及其受体可能在腋臭发病的过程中起了重要作用.腋臭相关基因(ABCC 11)中的单核甘酸多态性(SNP)很可能是患者发病的决定性因素.
腋臭的病因和髮病機製至今尚在研究中.ApoD蛋白可能是腋臭髮生分子機製中的覈心蛋白,研究錶明,頂泌汗腺的分泌物E-3M2H可能藉助ApoD蛋白為載體,從體錶散髮齣典型的辛辣氣味.ApoD基因自身及其調控因素的差異可能是疾病髮生的重要原因之一.在上述過程中,微生物的調控、雄激素及其受體可能在腋臭髮病的過程中起瞭重要作用.腋臭相關基因(ABCC 11)中的單覈甘痠多態性(SNP)很可能是患者髮病的決定性因素.
액취적병인화발병궤제지금상재연구중.ApoD단백가능시액취발생분자궤제중적핵심단백,연구표명,정비한선적분비물E-3M2H가능차조ApoD단백위재체,종체표산발출전형적신랄기미.ApoD기인자신급기조공인소적차이가능시질병발생적중요원인지일.재상술과정중,미생물적조공、웅격소급기수체가능재액취발병적과정중기료중요작용.액취상관기인(ABCC 11)중적단핵감산다태성(SNP)흔가능시환자발병적결정성인소.
The definite etiology and pathogenesis of axillary osmidrosis have not been elucidated yet.ApoD may be the key protein involved in the molecular pathogenesis of axillary osmidrosis.Latest studies have shown that (E)-3-methyl-2-hexenoic acid,which is secreted by apocrine sweat gland and is considered to be the principal axillary odor-related compound,is translocated to the surface of skin with Apo-D as the carrier.The development of axillary osmidrosis may be primarily attributed to the differences in Apo-D gene itself and variation in its regulatory factors.During the above process,the regulation by microorganisms,androgens and their receptors,may play an important role in the pathogenesis of axillary osmidrosis.In addition,the single nucleotide polymorphism (SNP) in the odor-related gene ABCC11 is probably the determinant factor for the development of axillary osmidrosis.