中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2012年
6期
739-741
,共3页
基质金属蛋白酶7/血液%膀胱肿瘤/代谢/病理学
基質金屬蛋白酶7/血液%膀胱腫瘤/代謝/病理學
기질금속단백매7/혈액%방광종류/대사/병이학
Matrix metalloproteinase 7/blood%Urinary bladder neoplasms/metabolism/pathology
目的 探讨血清基质金属蛋白酶7(matrix metalloproteinase-7,MMP-7)检测在膀胱癌诊断和预后中的意义.方法 选取77例膀胱癌患者和65例健康体检人群为研究对象.用ELISA方法测定血清MMP-7的水平.结果 膀胱癌组血清MMP-7水平高于正常对照组[3.1(0-32.1)ng/ml vs 1.0(0.2-2.6) ng/ml,x2=9.29,P=0.0023];膀胱癌患者血清MMP-7水平与淋巴结转移(x2=10.49,P＜0.01)和病理分期(x2=4.55,P=0.033)有关.血清MMP-7水平的ROC曲线下面积为0.810,诊断膀胱癌的灵敏度为83.6％,特异度为77.4％.高MMP-7水平的膀胱癌患者的生存率显著低于低MMP-7水平的膀胱癌患者(x2=3.88,P=0.0488).结论 MMP-7可能与膀胱癌的发生、发展和转移有关,血清MMP-7是膀胱癌的良好的诊断与预后指标.
目的 探討血清基質金屬蛋白酶7(matrix metalloproteinase-7,MMP-7)檢測在膀胱癌診斷和預後中的意義.方法 選取77例膀胱癌患者和65例健康體檢人群為研究對象.用ELISA方法測定血清MMP-7的水平.結果 膀胱癌組血清MMP-7水平高于正常對照組[3.1(0-32.1)ng/ml vs 1.0(0.2-2.6) ng/ml,x2=9.29,P=0.0023];膀胱癌患者血清MMP-7水平與淋巴結轉移(x2=10.49,P＜0.01)和病理分期(x2=4.55,P=0.033)有關.血清MMP-7水平的ROC麯線下麵積為0.810,診斷膀胱癌的靈敏度為83.6％,特異度為77.4％.高MMP-7水平的膀胱癌患者的生存率顯著低于低MMP-7水平的膀胱癌患者(x2=3.88,P=0.0488).結論 MMP-7可能與膀胱癌的髮生、髮展和轉移有關,血清MMP-7是膀胱癌的良好的診斷與預後指標.
목적 탐토혈청기질금속단백매7(matrix metalloproteinase-7,MMP-7)검측재방광암진단화예후중적의의.방법 선취77례방광암환자화65례건강체검인군위연구대상.용ELISA방법측정혈청MMP-7적수평.결과 방광암조혈청MMP-7수평고우정상대조조[3.1(0-32.1)ng/ml vs 1.0(0.2-2.6) ng/ml,x2=9.29,P=0.0023];방광암환자혈청MMP-7수평여림파결전이(x2=10.49,P＜0.01)화병리분기(x2=4.55,P=0.033)유관.혈청MMP-7수평적ROC곡선하면적위0.810,진단방광암적령민도위83.6％,특이도위77.4％.고MMP-7수평적방광암환자적생존솔현저저우저MMP-7수평적방광암환자(x2=3.88,P=0.0488).결론 MMP-7가능여방광암적발생、발전화전이유관,혈청MMP-7시방광암적량호적진단여예후지표.
Objective The aim of this study is to evaluate diagnostic and prognostic value of matrix metalloproteinase-7 (MMP-7) in patients with bladder cancer.Methods A total of 77 patients with bladder cancer and 65 healthy controls were recruited in this study.The levels of serum MMP-7 were measured by ELISA methods.Results The level of serum MMP-7 in bladder cancer group was significantly higher than those in the healthy control [ [ 3.1 (0 - 32.1 ) ng/ml vs 1.0 ( 0.2 - 2.6) ng/ml,x2 =9.29,P ＜0.01 ].The level of serum MMP-7 was correlated to lymph node metastasis ( x2=10.49,P ＜ 0.01 ) and tumor grade ( x2=4.55,P =0.033 ).Receiver operating characteristic ( ROC ) curves of serum MMP-7level was 0.810.Serum MMP-7 was used to diagnose bladder cancer with the sensitivity of 83.6％ and specificity of 77.4％.The survival rate in patients with a high level of MMP-7 was lower than that with a low level of MMP-7 (x2=3.88,P =0.0488).Conclusions MMP-7 may be closely associated with the progression of bladder cancer.Serum MMP-7 may be a useful index for diagnosis and prognosis for patients with bladder cancer.
