国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2012年
7期
900-902
,共3页
肝癌%白细胞介素-18%血管内皮生长因子%可溶性血管细胞粘附分子-1
肝癌%白細胞介素-18%血管內皮生長因子%可溶性血管細胞粘附分子-1
간암%백세포개소-18%혈관내피생장인자%가용성혈관세포점부분자-1
[Key words] Hepatic carcinoma%Interleukin-18%Vascular endothelial growth factor%Soluble vascular cell adhesion molecule- 1
目的 研究原发性肝癌( PHC)患者血清白细胞介素-18 (IL-18)、血管内皮生长因子(VEGF)与可溶性血管细胞粘附分子-1 (sVCAM-1)水平及临床意义.方法 采用双抗体夹心酶联免疫吸附法( ELISA)检测15例原发性肝癌患者治疗前后血清IL-18、VEGF、sVCAM-1水平,并与正常对照组比较.结果 PHC患者治疗前血清IL-18、VEGF、sVCAM-1较正常对照组明显升高(P均＜ 0.05); PHC患者治疗两周后血清IL-18、VEGF、sVCAM-1较治疗前降低(P均＜0.05),且较正常对照组仍有升高趋势(P均＜0.05).结论 原发性肝癌患者血清IL-18、VEGF、sVCAM-1水平增高,可能与原发性肝癌的发生、发展及侵袭有关.
目的 研究原髮性肝癌( PHC)患者血清白細胞介素-18 (IL-18)、血管內皮生長因子(VEGF)與可溶性血管細胞粘附分子-1 (sVCAM-1)水平及臨床意義.方法 採用雙抗體夾心酶聯免疫吸附法( ELISA)檢測15例原髮性肝癌患者治療前後血清IL-18、VEGF、sVCAM-1水平,併與正常對照組比較.結果 PHC患者治療前血清IL-18、VEGF、sVCAM-1較正常對照組明顯升高(P均＜ 0.05); PHC患者治療兩週後血清IL-18、VEGF、sVCAM-1較治療前降低(P均＜0.05),且較正常對照組仍有升高趨勢(P均＜0.05).結論 原髮性肝癌患者血清IL-18、VEGF、sVCAM-1水平增高,可能與原髮性肝癌的髮生、髮展及侵襲有關.
목적 연구원발성간암( PHC)환자혈청백세포개소-18 (IL-18)、혈관내피생장인자(VEGF)여가용성혈관세포점부분자-1 (sVCAM-1)수평급림상의의.방법 채용쌍항체협심매련면역흡부법( ELISA)검측15례원발성간암환자치료전후혈청IL-18、VEGF、sVCAM-1수평,병여정상대조조비교.결과 PHC환자치료전혈청IL-18、VEGF、sVCAM-1교정상대조조명현승고(P균＜ 0.05); PHC환자치료량주후혈청IL-18、VEGF、sVCAM-1교치료전강저(P균＜0.05),차교정상대조조잉유승고추세(P균＜0.05).결론 원발성간암환자혈청IL-18、VEGF、sVCAM-1수평증고,가능여원발성간암적발생、발전급침습유관.
Objective To investigate serum levels of interleukin-18 ( IL-18 ), vascular endothelial growth factor ( VEGF ),and soluble vascular cell adhesion molecule-1 ( sVCAM-1 ) in patients with primary hepatic carcinoma ( PHC ) and their clinical significance.Methods Serum levels of IL-18,VEGF,and sVCAM-1 were detected in 15 patients with PHC by enzyme-linked immunosorbent assay ( ELISA ) before and after treatment.The findings were compared with those from the healthy controls.Results The baseline levels of IL-18,VEGF,and sVCAM-1 were significantly higher in the patients with PHC than in the healthy controls ( P＜ 0.05 ).Levels of IL-18,VEGF,and sVCAM-1 were decreased two weeks after treatment as compared with the baselines ( P＜ 0.05 ),but were still higher than those from the healthy controls ( P ＜ 0.05 ).Conclusions An elevation in serum levels of IL-18,VEGF,and sVCAM-1 in patients with primary hepatic carcinoma may be associated with the genesis,development,and invasion of the malignancy.
