CAJ | 학술논문

目的探讨浸润性微乳头状癌(invasive micropapillary carcinoma,IMPC)和浸润性导管癌(invasive ductal carcinoma,IDC)的差异,分析乳腺浸润性微乳头状癌的临床病理及免疫组化特点.方法回顾性分析2004年10月至2007年11月51例浸润性微乳头状癌患者临床病理资料.选取同期临床病理资料完整的102例浸润性导管癌患者做对照.结果浸润性微乳头状癌和浸润性导管癌的乳头侵犯、淋巴管侵犯、淋巴结转移率、淋巴结转移水平、软组织侵犯、雌激素受体(estrogen receptor,ER)、孕激素受体(progestin receptor,PR)、三阴(ER,PR,HER2均为阴性)表达差异有统计学意义(P＜0.05).而闭经状态、发病侧别、淋巴结转移个数、人类表皮生长因子受体2(human epidermal growth factor receptor-2,HER2)表达及局部复发和远处器官转移差异无统计学意义.浸润性微乳头状癌组中位随访时间46个月(16～ 75个月),3年生存率和无病生存率分别为90.2％和84.3％.结论浸润性微乳头状癌是一种呈现侵袭性生长方式的少见乳腺癌类型,具有嗜淋巴特性和易发结外软组织侵犯的特点.乳腺浸润性微乳头状癌高表达激素受体,三阴乳腺癌比例较少.
목적 탐토침윤성미유두상암(invasive micropapillary carcinoma,IMPC)화침윤성도관암(invasive ductal carcinoma,IDC)적차이,분석유선침윤성미유두상암적림상병리급면역조화특점.방법 회고성분석2004년10월지2007년11월51례침윤성미유두상암환자림상병리자료.선취동기림상병리자료완정적102례침윤성도관암환자주대조.결과 침윤성미유두상암화침윤성도관암적유두침범、림파관침범、림파결전이솔、림파결전이수평、연조직침범、자격소수체(estrogen receptor,ER)、잉격소수체(progestin receptor,PR)、삼음(ER,PR,HER2균위음성)표체차이유통계학의의(P＜0.05).이폐경상태、발병측별、림파결전이개수、인류표피생장인자수체2(human epidermal growth factor receptor-2,HER2)표체급국부복발화원처기관전이차이무통계학의의.침윤성미유두상암조중위수방시간46개월(16～ 75개월),3년생존솔화무병생존솔분별위90.2％화84.3％.결론 침윤성미유두상암시일충정현침습성생장방식적소견유선암류형,구유기림파특성화역발결외연조직침범적특점.유선침윤성미유두상암고표체격소수체,삼음유선암비례교소.
Objective To elucidate the differences between invasive micropapillary carcinoma (IMPC) and invasive ductal carcinoma(IDC),and explore the clinicopathological and immunohistochemistry characteristics of invasive micropapillary carcinoma of the breast.Methods Invasive micropapillary carcinoma was identified in 51 patients by retrospective review of database from October 2004 to November 2007.Data were compared with 102 patients identified as invasive ductal carcinoma available in this hospital during the same period.Results Significant differences were observed in mammilla invasion,lymphatic vessel invasion,positivity of lymph node,lymph node metastatic level,extranodal extension,estrogen receptor,progestin receptor,triple negative between the two groups; while there was no significant differences between the two groups as to amenorrhea status,lesion laterality,number of metastatic lymph nodes,human epidermal growth factor receptor-2,local recurrence and distant organ metastasis.The median follow-up time of the invasive micropapillary carcinoma group were 46 months ( 16 - 75 months),and the 3-year overall survival and disease free survival was 90.2％ and 84.3％,respectively.Conclusions Invasive micropapillary carcinoma is a unique subtype of breast cancer which manifests an aggressive behavior tending to involve lymph node and extranodal soft tissues.Invasive micropapillary carcinoma of the breast had high expression of hormonal receptors,and triple negative breast cancer is less common in this type of breast cancer.