中国医药
中國醫藥
중국의약
CHINA MEDICINE
2009年
6期
448-449
,共2页
李建新%刘名霞%战玉喜%郑楠%战祥彩%张庆芸
李建新%劉名霞%戰玉喜%鄭楠%戰祥綵%張慶蕓
리건신%류명하%전옥희%정남%전상채%장경예
乙型病毒性肝炎%血管紧张素转化酶%胆碱酯酶%临床分型
乙型病毒性肝炎%血管緊張素轉化酶%膽堿酯酶%臨床分型
을형병독성간염%혈관긴장소전화매%담감지매%림상분형
Hepatitis B%Angiotensin-converting enzyme%Cholinesterase%Clinical classification
目的 探讨血清血管紧张素转化酶(ACE)与乙型病毒性肝炎不同临床分型的关系及临床意义.方法 利用连续监测法对健康组60例、慢性病毒性乙型肝炎组43例、Child-Pugh A级组36例、Child-Pugh B级组34例、Child-Pugh C级组32例各样本进行ACE活性和胆碱酯酶(CHE)活性的测定,比较各组ACE和CHE值,判断肝细胞损伤程度与血清ACE的活性及ACE和CHE之间的关系.结果 乙型病毒性肝炎不同临床分型血清中ACE活性变化的顺序由低到高为:健康组(23.47±6.03)μmol/L,慢性病毒性乙型肝炎组(51.79±8.58)μmol/L,乙肝后肝硬化中Child-Pugh A级组(60.57±6.40)μmol/L,Child-Pugh B级组(68.22±6.62)μmol/L,Child-Pugh C级组(77.30±8.30)μmol/L,各组肝病患者血清ACE活性都明显高于健康组(P<0.01).CHE活性>4000 IU/L时,ACE活性为(34.71±9.43)μmol/L,CHE在2000-4000 IU/L时,ACE活性为(53.16±8.46)μmol/L,CHE在1000～2000 IU/L时,ACE活性为(67.67±9.52)μmol/L,CHE<1000 IU/L时,ACE活性为(79.27±7.53)μmol.L,各组间比较,差异有统计学意义(均P<0.01).结论 检测病毒性乙型肝炎不同临床分型中血清ACE的活性变化,对于判断肝细胞损伤程度有-定的临床意义.
目的 探討血清血管緊張素轉化酶(ACE)與乙型病毒性肝炎不同臨床分型的關繫及臨床意義.方法 利用連續鑑測法對健康組60例、慢性病毒性乙型肝炎組43例、Child-Pugh A級組36例、Child-Pugh B級組34例、Child-Pugh C級組32例各樣本進行ACE活性和膽堿酯酶(CHE)活性的測定,比較各組ACE和CHE值,判斷肝細胞損傷程度與血清ACE的活性及ACE和CHE之間的關繫.結果 乙型病毒性肝炎不同臨床分型血清中ACE活性變化的順序由低到高為:健康組(23.47±6.03)μmol/L,慢性病毒性乙型肝炎組(51.79±8.58)μmol/L,乙肝後肝硬化中Child-Pugh A級組(60.57±6.40)μmol/L,Child-Pugh B級組(68.22±6.62)μmol/L,Child-Pugh C級組(77.30±8.30)μmol/L,各組肝病患者血清ACE活性都明顯高于健康組(P<0.01).CHE活性>4000 IU/L時,ACE活性為(34.71±9.43)μmol/L,CHE在2000-4000 IU/L時,ACE活性為(53.16±8.46)μmol/L,CHE在1000～2000 IU/L時,ACE活性為(67.67±9.52)μmol/L,CHE<1000 IU/L時,ACE活性為(79.27±7.53)μmol.L,各組間比較,差異有統計學意義(均P<0.01).結論 檢測病毒性乙型肝炎不同臨床分型中血清ACE的活性變化,對于判斷肝細胞損傷程度有-定的臨床意義.
목적 탐토혈청혈관긴장소전화매(ACE)여을형병독성간염불동림상분형적관계급림상의의.방법 이용련속감측법대건강조60례、만성병독성을형간염조43례、Child-Pugh A급조36례、Child-Pugh B급조34례、Child-Pugh C급조32례각양본진행ACE활성화담감지매(CHE)활성적측정,비교각조ACE화CHE치,판단간세포손상정도여혈청ACE적활성급ACE화CHE지간적관계.결과 을형병독성간염불동림상분형혈청중ACE활성변화적순서유저도고위:건강조(23.47±6.03)μmol/L,만성병독성을형간염조(51.79±8.58)μmol/L,을간후간경화중Child-Pugh A급조(60.57±6.40)μmol/L,Child-Pugh B급조(68.22±6.62)μmol/L,Child-Pugh C급조(77.30±8.30)μmol/L,각조간병환자혈청ACE활성도명현고우건강조(P<0.01).CHE활성>4000 IU/L시,ACE활성위(34.71±9.43)μmol/L,CHE재2000-4000 IU/L시,ACE활성위(53.16±8.46)μmol/L,CHE재1000～2000 IU/L시,ACE활성위(67.67±9.52)μmol/L,CHE<1000 IU/L시,ACE활성위(79.27±7.53)μmol.L,각조간비교,차이유통계학의의(균P<0.01).결론 검측병독성을형간염불동림상분형중혈청ACE적활성변화,대우판단간세포손상정도유-정적림상의의.
Objective To discuss the angiotensin-converting enzyme (ACE) changes in different clinical sub-types of hepatitis B. Methods The fully automatic biochemical analyzer was used to detect ACE activity and to measure acetylcholine esterase activity (CHE) in samples from the different groups. Results Serum ACE activity among the different clinical sub-types was as follows: control group(23.47±6.03 )μmob/L; chronic viral hepatitis B (51.79±8.58) μmol/L; liver cirrhosis Child-Pugh A (60.57±6.4)μmol/L; liver cirrhosis Child-Pugh B (68.22 ±6.62)μmol/L; liver cirrhosis Child-Pugh C (77.3±8.3 )μmol/L Serum ACE activity in patients with virus hepatitis B was significantly higher than that in the control greup(P <0.01). When CHE was >4000 IU/L, the activity of ACE was(34.71±9.43 )μg/L. The differences between each group were all significant (P<0.01).Conclusion Serum activity of ACE in clinical sub-types of hepatitis B had clinical significance for assessing the degree of liver cell injury.
