中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2010年
26期
24-26
,共3页
胡波勇%韩明%龚仁杰%邱劲%朱宏刚
鬍波勇%韓明%龔仁傑%邱勁%硃宏剛
호파용%한명%공인걸%구경%주굉강
前列腺炎%干扰素Ⅱ型%白细胞介素10%慢性盆腔疼痛综合征
前列腺炎%榦擾素Ⅱ型%白細胞介素10%慢性盆腔疼痛綜閤徵
전렬선염%간우소Ⅱ형%백세포개소10%만성분강동통종합정
Prostatitis%Interferon type Ⅱ%Interleukin-10%Chronic pelvic pain syndrome
目的 探讨干扰素-γ(IFN-γ)、白细胞介素-10(IL-10)在慢性前列腺炎(CP)/慢性盆腔疼痛综合征(CPPS)患者前列腺液(EPS)中的表达及临床意义.方法 选取20例前列腺炎ⅢA型患者(A组),20例前列腺炎ⅢB型患者(B组),10例健康对照者(对照组),采用双抗体夹心ABC-ELISA法测定三组患者EPS中IFN-γ、IL-10含量,并按国际前列腺炎症状评分标准(NIH-CPSI)进行相关性研究.结果 IFN-γ在A组和B组EPS中的表达水平分别为(14.92±7.85)ng/L和(13.74±5.96)ng/L,均明显高于对照组(7.47±1.40)ng/L(P＜0.05).IL-10在A组和B组EPS中的表达水平分别为(216.40±33.65)ng/L和(223.70±45.21)ng/L,亦明显高于对照组(162.10±43.81)ng/L(P＜0.05).但A组和B组间比较差异无统计学意义(P＞0.05).EPS中IFN-γ、IL-10的水平与NIH-CPSI评分无相关性(P＞0.05).结论 EPS中细胞因子(IFN-γ、IL-10)在CP/CPPS的病理学改变中起重要作用,可作为CP/CPPS的诊断参考依据之一.
目的 探討榦擾素-γ(IFN-γ)、白細胞介素-10(IL-10)在慢性前列腺炎(CP)/慢性盆腔疼痛綜閤徵(CPPS)患者前列腺液(EPS)中的錶達及臨床意義.方法 選取20例前列腺炎ⅢA型患者(A組),20例前列腺炎ⅢB型患者(B組),10例健康對照者(對照組),採用雙抗體夾心ABC-ELISA法測定三組患者EPS中IFN-γ、IL-10含量,併按國際前列腺炎癥狀評分標準(NIH-CPSI)進行相關性研究.結果 IFN-γ在A組和B組EPS中的錶達水平分彆為(14.92±7.85)ng/L和(13.74±5.96)ng/L,均明顯高于對照組(7.47±1.40)ng/L(P＜0.05).IL-10在A組和B組EPS中的錶達水平分彆為(216.40±33.65)ng/L和(223.70±45.21)ng/L,亦明顯高于對照組(162.10±43.81)ng/L(P＜0.05).但A組和B組間比較差異無統計學意義(P＞0.05).EPS中IFN-γ、IL-10的水平與NIH-CPSI評分無相關性(P＞0.05).結論 EPS中細胞因子(IFN-γ、IL-10)在CP/CPPS的病理學改變中起重要作用,可作為CP/CPPS的診斷參攷依據之一.
목적 탐토간우소-γ(IFN-γ)、백세포개소-10(IL-10)재만성전렬선염(CP)/만성분강동통종합정(CPPS)환자전렬선액(EPS)중적표체급림상의의.방법 선취20례전렬선염ⅢA형환자(A조),20례전렬선염ⅢB형환자(B조),10례건강대조자(대조조),채용쌍항체협심ABC-ELISA법측정삼조환자EPS중IFN-γ、IL-10함량,병안국제전렬선염증상평분표준(NIH-CPSI)진행상관성연구.결과 IFN-γ재A조화B조EPS중적표체수평분별위(14.92±7.85)ng/L화(13.74±5.96)ng/L,균명현고우대조조(7.47±1.40)ng/L(P＜0.05).IL-10재A조화B조EPS중적표체수평분별위(216.40±33.65)ng/L화(223.70±45.21)ng/L,역명현고우대조조(162.10±43.81)ng/L(P＜0.05).단A조화B조간비교차이무통계학의의(P＞0.05).EPS중IFN-γ、IL-10적수평여NIH-CPSI평분무상관성(P＞0.05).결론 EPS중세포인자(IFN-γ、IL-10)재CP/CPPS적병이학개변중기중요작용,가작위CP/CPPS적진단삼고의거지일.
Objective To investigate the levels of pro-inflammatory cytokine interferon (IFN)-γand anti-inflammatory cytokine interlenkin (IL)-10 in expressed prostatic secretions (EPS) of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and their clinical significance. Methods The levels of IFN-γ and IL-10 in EPS of 20 patients with CP (type Ⅲ A, group A ), 20 patients with CPPS (type Ⅲ B,group B) and 10 healthy men (control group) were measured using enzyme-linked immunosorbent assay (ELISA). The results were analyzed comparatively with NIH-chronic prostatitis symptom index (NIH-CPSI).Results The levels of IFN-γ in EPS of group A and group B were ( 14.92 ± 7.85 ), ( 13.74 ± 5.96) ng/L respectively, which were higher than that in control group [(7.47 ± 1.40) ng/L] (P ＜ 0.05 ). And the levels of IL-10 in EPS of group A and group B were (216.40 ± 33.65 ), (223.70 ± 45.21 ) ng/L respectively, which were higher than that in control group [( 162.10 ± 43.81 ) ng/L] ( P ＜ 0.05 ). There was no statistically significant difference between group A and group B. No correlation between NIH-CPSI and IFN- γ,IL-10 levels in EPS(P ＞ 0.05 ). Conclusion IFN-γ and IL-10 have a very important role in etiology of CP/CPPS and they can be the objective parameters in the diagnosis of CP/CPPS.
